The hottest Health Substack posts right now

And their main takeaways
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Top Technology Topics

assessing the case for pardoning fauci

bad cattitude • 233 implied HN points • 15 Jan 25
🇺🇸 U.S. Politics Politics Law Health Public Policy Government
  1. Pardoning Fauci may send a message that he is being protected from accountability. This could shape public opinion in favor of Fauci rather than promote transparency.
  2. Many people are not aware of the controversies surrounding the NIH's role in COVID-19. It's important to publicize the facts to educate the general public.
  3. There should be accountability for public figures like Fauci. Exposing the truth about their actions can help prevent similar issues in the future.

The Japanification of Work: Lessons from an Ageing Nation

Workforce Futurist by Andy Spence • 293 implied HN points • 22 Jan 25
💼 Business Workforce Economy Demographics Health Technology
  1. Japan is facing a major challenge with an aging population, as more people are over 65 than under 5. This creates pressure on the economy and social systems.
  2. To tackle the labor shortage, Japan is using technology like robots and exoskeletons to support care workers and assist the elderly. Employers are also adjusting work policies to help older workers.
  3. Other countries can learn from Japan's approach to handle aging populations by rethinking retirement, encouraging women in the workforce, and being open to skilled immigration.

Thinking points, February 9, 2024

uTobian • 7311 implied HN points • 10 Feb 24
🇺🇸 U.S. Politics Health Government Society Media Policy
  1. Logic and reason are important and should not be banned, even if powerful entities try to suppress them.
  2. The biggest global risks in 2024 involve various organizations and entities that hold significant power and influence.
  3. Vaccines and the pharmaceutical industry are controversial topics, with strong opinions about their safety and impact.

The Case for 2 mSv/day. 2.0.

Gordian Knot News • 139 implied HN points • 04 Feb 25
🔬 Science Radiation Health Biology Environment Nuclear
  1. The historical dose limit for radiation exposure was set at 2 mSv per day, based on a time when no harmful effects were clearly detected. This suggests that at this level of exposure, there might not be significant health risks.
  2. Our body has a strong system for repairing DNA damage caused by radiation and natural processes. Most DNA issues are fixed quickly, which means low-level radiation may not lead to serious health problems.
  3. If we accept that 2 mSv per day is safe, it could change how we manage nuclear power. It may allow for safer operations and reduce unnecessary evacuations, ultimately making energy cheaper and more sustainable.
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High-Throughput Chemistry and Engineering with Kadi Saar

Lever • 19 implied HN points • 24 Oct 24
🔬 Science Chemistry Biotechnology Engineering Research Health
  1. Kadi Saar has an impressive background in both chemistry and engineering. She excelled in academics and sports, even winning a talent show in mental arithmetic.
  2. Her research focuses on combining high-throughput structural biology with computational chemistry to help develop new drugs. She has shown that analyzing diverse ligand structures can lead to better drug design.
  3. Kadi emphasizes the importance of enjoying the people you work with when choosing projects. Collaborating with good people makes the journey more fulfilling.

Gene-environment interactions: ubiquitous yet undetectable

The Infinitesimal • 359 implied HN points • 21 Aug 24
🔬 Science Genetics Health Environment Statistics Evolution
  1. Gene-environment interactions (GxE) are common but hard to identify in humans. They show how genetic traits can change in different environments, affecting how we understand traits like obesity or education.
  2. There are different models to explain how genes and environments work together. Some models show that environments can amplify or change the effects of multiple genetic variants on traits.
  3. Research has found that environmental factors, like socioeconomic status or education quality, can significantly influence how genetic variations are expressed, meaning genetics alone doesn't tell the whole story about traits.

If We Solve Aging

David Friedman’s Substack • 251 implied HN points • 21 Jan 25
🔬 Science Aging Health Technology Society Politics
  1. There isn't a single fix for aging; it's a complex issue that requires addressing many changes in the body. Solving one part of the problem might only add a few years to life expectancy.
  2. If people lived for centuries, they might change careers or take more leisurely paths in life. This could lead to many people retiring early, but society still needs workers for essential tasks.
  3. Without aging, older politicians could hold power indefinitely, affecting society's decision-making. This might lead to less innovation and a government influenced more by the old than the young.

Après Sport

Snaxshot • 679 implied HN points • 18 Aug 24
🍲 Food & Drink Beverages Trends Health Culture Recreation
  1. Après sport drinks are a trendy new category that focuses on hydration without the heavy functionality of traditional sports drinks. They are designed to be enjoyed socially after light sports like pickleball or tennis.
  2. Millennials are reviving and upgrading leisure sports and related drinks, moving away from sugary beverages towards healthier options like sparkling waters. This reflects a broader shift in lifestyle and drinking habits.
  3. Market trends show a growing demand for low-calorie and functional drinks, with the sports drink sector expected to see significant growth. People are starting to prefer lighter, refreshing choices after sports activities.

Level Up Challenge: Week One

Running Probably • 119 implied HN points • 04 Oct 24
🎾 Sports Running Fitness Training Health Wellness
  1. Everyone is at a different stage in their running journey, and that's okay. Whether you're just starting or you're a seasoned runner, there's a place for you.
  2. The Level Up Challenge has different levels for various runners, from beginners trying to build a habit to advanced runners seeking to improve speed and training. This can help everyone identify where they fit and what goals to set.
  3. Keep a running journal to reflect on your experiences and progress. Writing down thoughts about your runs can help you understand how running affects you, both mentally and physically.

"Like Trader Joe's on Ayahuasca"

Snaxshot • 739 implied HN points • 12 Aug 24
🍲 Food & Drink Trends Products Brands Health Recipes
  1. Gen Z is moving away from traditional recipes and ingredients. They like to remix old favorites with new, exciting flavors and trends.
  2. There's a rising trend of niche and locally sourced water brands. Many consumers are now interested in hyper-local options rather than exotic imported waters.
  3. Food brands are finding success by unbundling popular classics. This gives consumers new and fun ways to enjoy familiar products.

A Story About Pain

The Audacity. • 10770 implied HN points • 13 Sep 23
🎭️ Culture Gender Emotions Health
  1. The post discusses women, pain, and the struggle to be heard
  2. The author, Aubrey Hirsch, shares personal stories through writing and illustrations
  3. Aubrey Hirsch's work has been featured in various publications like The New York Times and TIME

Keeping it in the Family

Wrong Side of History • 508 implied HN points • 13 Dec 24
🎭️ Culture Marriage Society Health History Religion
  1. Cousin marriage was common among British nobility in the past, but its prevalence has declined due to health concerns and changing cultural norms. Many people were worried about its effects on children's health.
  2. The Catholic Church has historically opposed cousin marriages to promote social ties beyond the family, which helped shape modern democratic societies and reduce corruption.
  3. Despite health risks, cousin marriage remains popular in some communities, providing social and financial support. This can create strong networks but also lead to higher chances of genetic disorders in children.

Bioaccelerationism Is a No-Brainer

Richard Hanania's Newsletter • 2682 implied HN points • 20 Dec 24
🕹 Technology Biotech AI Innovation Health Ethics
  1. Bioaccelerationism focuses on advancing biotechnology that improves reproduction, making it easier for couples to have children. New methods are coming out that can help reduce the stress and difficulty associated with traditional fertility treatments like IVF.
  2. Unlike some technologies that can quickly change the world, biotechnology develops slowly, giving society time to understand its effects. This means we can monitor and ensure safety as new methods emerge over time.
  3. The goals of biotech often align with the needs of parents and society. Developing health, intelligence, and beauty can benefit everyone, and the risks are generally limited to individuals or families rather than posing a threat to society as a whole.

Girl Storm (2023) by Peg Kerswell

Tao Lin • 599 implied HN points • 22 Jul 24
📚 Literature Memoir Autism Health Parenting Self-help
  1. Raising a profoundly autistic child can be incredibly challenging and heartbreaking. The author shares true stories of frustration and helplessness while caring for her daughter Ellie.
  2. There is a growing concern about the rising cases of profound autism, with the author questioning the commonly held belief that autism is purely genetic. The book highlights the potential roles of diet and environmental factors.
  3. Despite the struggles, the memoir offers a perspective that can cultivate gratitude in readers. It serves as a reminder of the importance of support and love in difficult circumstances.

Invisible feedback loops: How the body shapes the brain

Brain Pizza • 662 implied HN points • 27 Nov 24
🔬 Science Neuroscience Cognition Health Biology Philosophy
  1. The brain is not separate from the body; they work together in complex ways. Understanding how they interact can give us better insights into health and disease.
  2. Various bodily factors like gut health, muscle activity, and fat can influence how our brain functions. This shows the importance of considering the whole body when studying the brain.
  3. Topics like cancer cachexia and the gut-brain axis highlight specific connections between body signals and brain function, which can impact cognitive health.

No human genes have truly 100% penetrance

Trevor Klee’s Newsletter • 970 implied HN points • 10 Nov 24
🔬 Science Genetics Molecular Biology Health Bioethics Research
  1. No human genes have 100% penetrance, meaning not all who have a certain gene will show the related traits. This makes predicting health outcomes based on genetics challenging.
  2. Genetic diseases like Huntington's seem like they have high penetrance, but variability in symptoms and onset can make them unpredictable. It highlights the complexity of genetics beyond simple Mendelian traits.
  3. The body's systems, especially the immune system, add layers of complexity that affect how genes express themselves. This makes it really hard to guarantee that a specific gene will always result in the same outcome.

A slightly tipsy investigation into my wife's superpower

Experimental History • 7657 implied HN points • 13 Feb 24
🔬 Science Research Psychology Education Culture Health
  1. Some people have unique sensory abilities that others may not understand or share, like detecting the lingering smell of eggs on plates even after washing.
  2. Being open-minded and receptive to new ideas is important to avoid rigidity in thinking and to continuously learn and grow.
  3. Academic professions, like journal publishing and university rankings, can sometimes involve questionable practices that prioritize profit over knowledge or ethics.

15 things I consumed this week

Maybe Baby • 680 implied HN points • 15 Nov 24
🎭️ Culture Media Lifestyle Food Health Family
  1. Taking care of a sick family can be really tough. It can feel like you're in a never-ending cycle of illness, especially with little kids.
  2. Staying home while everyone is sick makes you feel kind of trapped. It can be really challenging but finding little joys at home can help.
  3. Being open about struggles, like family sickness, helps build connection. It's important to share and talk about these experiences with others.

Interesting reads, November 2024 edition

Brain Pizza • 529 implied HN points • 19 Nov 24
🔬 Science Health Technology Psychology Environment Society
  1. The new 'Collective Minds' lab focuses on understanding how we think as a group. It's an interesting place to explore collective thought.
  2. Smartphones are often blamed for many problems in the world, but there might be other factors contributing to these issues.
  3. There's ongoing research about how our brain reacts to stories while watching movies. It's cool to see how our thoughts are tied to brain activity.

Pfizer and Moderna bivalent vaccines contain 20-35% expression vector and are transformation competent in E.coli

Nepetalactone Newsletter • 5405 implied HN points • 08 Mar 23
🔬 Science Health Research Vaccines Contamination
  1. Pfizer and Moderna bivalent vaccines have 20-35% expression vector and can transform E.coli.
  2. Previous estimates of DNA contamination in the vaccines were significantly underestimated.
  3. Different methods like transformation of DNA in E.coli and qPCR assays were used to quantify the nucleic acid contamination in the vaccines.

Minimal Evidence of Heterogeneity in Effect Estimates: GWAS from the Million Veteran Program

The Infinitesimal • 319 implied HN points • 19 Jul 24
🔬 Science Genetics Research Health Diversity Medicine
  1. The Million Veteran Program's study looked at genetic data from 600,000 people, revealing that diversity in ancestry helped identify genetic traits linked to diseases.
  2. Most genetic differences between groups were due to allele frequency changes rather than real differences in how genes affect health.
  3. Fewer than 1% of significant genetic associations showed differences between populations, indicating that many genetic effects are quite similar across different ancestry groups.

News! & Longer Living Through Chemistry

Unsettled Science • 545 implied HN points • 26 Oct 24
🔬 Science Research Health Chemistry Lifestyle Wellness
  1. A new Substack newsletter is being launched due to challenges faced in a joint project. Leaving the previous newsletter was not an easy decision but necessary to move forward.
  2. There is a mention of an anti-aging pill in the news. It's important to think carefully about whether to take such a pill or not.
  3. The focus is on exploring longer life through chemistry. This suggests that science might hold keys to better health and longevity.

All models are wrong, but some are tragically misleading

Gordian Knot News • 183 implied HN points • 30 Dec 24
🔬 Science Nuclear Radiation Health Environment Policy
  1. Evacuating people from the Fukushima area was delayed, and some evacuation decisions may not have been based on the actual risk levels involved. This led to unnecessary stress for many residents.
  2. A lot of the radiation exposure from the Fukushima disaster was less harmful than initially thought. Some areas had low radiation levels that people were advised to evacuate from, leading to disruption in their lives.
  3. Models predicting cancer risks from radiation exposure can be misleading. In some cases, the predicted health impacts did not match what real-life studies showed.

We had people go into rooms of our parents, grand-parents, who were isolated behind the glass, no doctor would touch them as they began to die in isolation; pull back cover saw feces, mound of feces

Alexander News Network -Dr. Paul Elias Alexander's substack • 2299 implied HN points • 17 Jan 24
🏥 Health Politics Health
  1. Patients were left isolated and uncared for, even as they died in filth.
  2. The author advocates for holding medical professionals accountable for their actions during COVID.
  3. The text urges for dramatic legal consequences if COVID policies are found to be harmful.

Science Fictions links for November 2024

Science Fictions • 275 implied HN points • 02 Dec 24
🔬 Science Research Health Technology Education Ethics
  1. Alzheimer's research is still struggling, with some drugs not working as expected despite years of studies.
  2. There are problems in scientific publishing, like peer reviews being partly written by AI and retracted papers not giving clear explanations of their issues.
  3. Scandals and fraud in science keep happening, affecting public trust and raising questions about the credibility of some research.

BOOM! “Bill Gates has done more damage to the world's health than probably any other individual." ~ Professor Angus Dalgleish (professor of oncology at St George's, University of London)

Alexander News Network -Dr. Paul Elias Alexander's substack • 2181 implied HN points • 11 Jan 24
🏥 Health Politics Health
  1. Professor Angus Dalgleish believes Bill Gates has done significant damage to global health.
  2. Criticism is directed at pharmaceutical companies for experimenting with harmful research protocols and vaccines on poor populations.
  3. The pursuit of money and power in the pharmaceutical industry is highlighted as detrimental, especially to vulnerable communities.

The Total Dose Cult

Gordian Knot News • 124 implied HN points • 06 Jan 25
🔬 Science Radiation Health Risk Assessment Nuclear Biology
  1. Total dose of radiation can be misleading. It's not just about how much radiation someone gets, but also how quickly they receive it.
  2. People exposed to radiation over a long time can have different health risks compared to those who are exposed quickly. The way their body processes radiation can vary.
  3. When discussing radiation harm, it's important to consider the rate at which people are exposed. This helps to get a clearer understanding of potential risks.

Perils of Flawed Meta-Analytic Methodology

The Shores of Academia • 39 implied HN points • 03 Oct 24
🔬 Science Health Research Statistics Psychology Methodology
  1. Flawed meta-analysis can mix different studies that aren't similar, making it hard to draw clear conclusions about their effects on things like mental health.
  2. It’s important for researchers to look at specific impacts and not just assume that a random-effects model explains everything. Understanding the differences in outcomes can lead to better insights.
  3. Proper analysis in studies is really important, especially when people's health is at risk. Ignoring negative findings can mislead people about the safety of products like drugs.

Womb

The Audacity. • 3282 implied HN points • 14 Jun 23
📚 Literature Essay Health
  1. Kristina Kasparian is an emerging writer from Montreal, Canada.
  2. She holds a Ph.D. in neurolinguistics but left academia due to health reasons.
  3. Her essay 'Womb' is available for paid subscribers on audacity.substack.com.

Will some Democrat Senators vote for RFK Jr?

Vinay Prasad's Observations and Thoughts • 107 implied HN points • 10 Jan 25
🇺🇸 U.S. Politics Elections Policy Health Senate Political Reform
  1. Some Democrat Senators might support RFK Jr. because they believe he can bring about important changes, especially in food policies and health regulations.
  2. Concerns about infectious diseases like measles and polio are overshadowed by the more pressing issues of chronic diseases caused by poor diet and exposure to harmful substances.
  3. Partisan politics and groupthink may prevent more Democrats from supporting RFK Jr., even when they see the benefits he could provide in health and wellness.