The hottest Metabolism Substack posts right now

And their main takeaways
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Top Science Topics

ex150-9 review: Down 4lbs, broke through 220lbs

Experimental Fat Loss • 106 implied HN points • 18 Mar 24
🏥 Health & Wellness Metabolism
  1. Decision-making dilemma: stick to what works or explore new options. It's tricky to find the balance.
  2. Balancing exploitation and exploration in weight loss experiments is key to progress. Trying new things can build confidence, but sticking to what's known to work is crucial for consistent results.
  3. It's important to evaluate the success of experiments and prioritize proven methods. Understanding mechanisms behind weight loss can lead to more effective strategies.

Seed Oils explain the 8 Mysteries of Obesity

Experimental Fat Loss • 176 implied HN points • 22 Jul 23
🏥 Health & Wellness Metabolism
  1. Obesity is caused by long-term dysfunction of mitochondrial energy metabolism, mainly due to changes in food intake starting in the late 1800s and increased seed oil consumption since the 1930s and 1970s.
  2. The drastic increase in obesity rates since the mid-1970s can be attributed to the rise in seed oil consumption, such as the introduction of canola oil in the 1970s.
  3. The ongoing obesity crisis, even since 2010, has seen a massive increase due to a 50% rise in seed oil consumption like soybean oil.

Wellbeing: The Accelerating Obesity Crisis

Who is Robert Malone • 18 implied HN points • 19 Jun 25
🏥 Health & Wellness Metabolism
  1. Restricting the amino acid cysteine in your diet may help with weight loss. It seems that lower levels of cysteine can make fat burn more calories and reduce inflammation.
  2. Ultra-processed foods are linked to weight gain in America. Eating less processed food can lead to eating fewer calories and can support weight loss.
  3. Many processed foods have added cysteine, which can contribute to weight gain. Improved labeling on food products could help people make better choices about what they eat.

Reversing obesity != getting shredded

Experimental Fat Loss • 141 implied HN points • 21 Oct 23
🏥 Health & Wellness Metabolism
  1. Reversing obesity is not the same as achieving a shredded body like bodybuilders do.
  2. Starving yourself to extreme levels, like bodybuilders do, is not a sustainable or healthy method to reverse obesity.
  3. Using a strategy meant for bodybuilders, such as extreme dieting, to reverse obesity can be detrimental to your health in the long run.
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Not losing fat on Keto/Carnivore? Try eating less protein.

Experimental Fat Loss • 141 implied HN points • 27 May 23
🏥 Health & Wellness Metabolism
  1. Eating high protein might hinder fat loss on Keto/Carnivore diets; consider reducing protein intake.
  2. Popular Keto/Carnivore diets emphasize high protein, but excessive protein intake may not be suitable for everyone.
  3. Moderating protein intake and focusing on adequate fat consumption is essential for maintaining a balanced diet on Keto/Carnivore.

The Mysterious Case of Outlier 17

Experimental Fat Loss • 106 implied HN points • 07 Oct 23
🏥 Health & Wellness Metabolism
  1. Outlier 17 lost a significant amount of weight on the Half-Tato diet, which was only 50% potatoes and 50% regular food, with the main focus on how her approach ties into eliminating PUFAs, limiting protein intake, and focusing on a specific macronutrient.
  2. The Half-Tato diet study compared to other experiments led to observations that avoiding PUFAs, keeping protein intake low, and following a specific macro balance might contribute significantly to weight loss.
  3. Outlier 17's success might be due to factors like avoidance of PUFAs, low protein intake, and focus on a specific macro balance, indicating potential keys to effective weight loss.

What it's Like to Have a Homeostat

The Heart Attack Diet • 19 implied HN points • 02 Sep 23
🏥 Health & Wellness Metabolism
  1. Weight can be maintained consistently over time with a well-functioning homeostat, regardless of lifestyle or diet changes.
  2. Consistent physical activity and high calorie consumption did not impact the author's weight due to their stable homeostat.
  3. Even drastic changes like cycling across a country and significant weight loss were corrected quickly by the homeostat to maintain a stable weight.

Appetite is the Key to the Obesity Epidemic

The Heart Attack Diet • 19 implied HN points • 27 Aug 23
🏥 Health & Wellness Metabolism
  1. Some individuals feel hungry constantly, spending hours resisting hunger or eating until their stomachs hurt.
  2. Feeling physically full is different from stopping wanting food. It's about reaching a point where you don't desire to eat more even if food is available.
  3. The absence of the feeling of satiety can lead people to overeat until their stomachs hurt, contributing to the mystery of the obesity epidemic.

Your “MTHFR” Is Just a Riboflavin Deficiency

Harnessing the Power of Nutrients • 299 implied HN points • 26 Feb 19
🏥 Health & Wellness Metabolism
  1. MTHFR is an important enzyme involved in methylation, and deficiencies can lead to various health issues. Common genetic variations like C677T and A1298C can impair MTHFR activity.
  2. The solution starts with ensuring an adequate intake of riboflavin, which plays a crucial role in supporting MTHFR function. This requires a dietary adjustment and potentially exploring a specific protocol.
  3. Beyond riboflavin, addressing other nutrient deficiencies and genetic impairments related to energy metabolism is crucial for optimizing MTHFR activity. Comprehensive screenings can help identify these underlying issues for effective solutions.

Kraft test results: still insulin resistant

Experimental Fat Loss • 77 implied HN points • 30 Aug 23
🏥 Health & Wellness Metabolism
  1. Insulin resistance can exist with normal glucose levels, especially after years on a ketogenic diet.
  2. Measuring fasting insulin levels can be a better indicator of insulin resistance than glucose levels.
  3. The Kraft test, which measures insulin response over time after a meal, can provide more insights into metabolic health than traditional glucose tests.

Bigger Livers?

Rough Diamonds • 21 implied HN points • 08 Nov 24
🏥 Health & Wellness Metabolism
  1. Bigger athletes tend to have larger livers, and this contributes to their higher resting metabolic rates. This means they burn more energy even when not exercising, allowing them to eat more without gaining weight.
  2. Eating a higher-protein diet appears to promote liver growth. This suggests that if you want a bigger liver, increasing your protein intake along with exercise might help.
  3. Some methods to artificially increase liver size can lead to serious health issues, like cancer. It's better to focus on safe and natural ways to promote liver health, such as diet and exercise.

Iron

Harnessing the Power of Nutrients • 39 implied HN points • 08 Jul 22
🏥 Health & Wellness Metabolism
  1. Iron is crucial for various aspects of health, including the thyroid, energy metabolism, and antioxidant functions.
  2. Despite its importance, iron also has a dark side that should be considered.
  3. Exploring the role of iron in the body can offer insights into its significance beyond just being the substance of blood.

Chapter 25: Science of Nutrition in Modern Health- Part 1

Spyderdoc Newsletter • 19 implied HN points • 09 Nov 24
🏥 Health & Wellness Metabolism
  1. Our bodies need food for survival, but it's important to choose the right foods to stay healthy. Understanding what we eat helps us make better choices for longevity.
  2. Hormones like ghrelin and leptin control our hunger and fullness. These hormones play a big role in how much we eat and can affect our weight.
  3. The way we process food has changed a lot over time. Today, many people eat more sugars and processed foods, leading to overeating and weight gain. We need to be mindful of our eating habits and try to eat healthier.

045: Why You Should Manage Your Riboflavin Status and How to Do It

Harnessing the Power of Nutrients • 139 implied HN points • 16 Feb 19
🏥 Health & Wellness Metabolism
  1. Riboflavin is crucial for various bodily functions, including energy metabolism, antioxidant system, and methylation.
  2. Assessing riboflavin status accurately is essential; riboflavin supplements may vary in effectiveness based on individual health conditions.
  3. Consuming dietary sources rich in riboflavin, like liver and milk, can help maintain optimal riboflavin status.

046: Niacin, Part 1: What It Is and Why You Need It

Harnessing the Power of Nutrients • 119 implied HN points • 01 Mar 19
🏥 Health & Wellness Metabolism
  1. Niacin is crucial for various bodily functions, such as neurotransmitter release, skin repair from sun exposure, and cell turnover in the intestines.
  2. Aging and illness deplete niacin, making supplementation important to combat damage and promote overall health.
  3. High doses of niacin can have negative effects, like liver damage, by depleting methyl groups. Understanding the risks and benefits of niacin supplementation is essential.

ex150-5: Recarb and Water Weight Regain

The Heart Attack Diet • 1 HN point • 30 Apr 24
🏥 Health & Wellness Metabolism
  1. Transitioning from a ketogenic diet back to a more carb-inclusive diet can result in water-weight regain, sometimes unexpectedly.
  2. Changes in diet composition can impact how one feels physically, such as experiencing tiredness or sluggishness after reintroducing specific foods.
  3. Monitoring and understanding fluctuations in weight, especially water weight, when altering diet and carb consumption is essential to gauge the body's response.

We Used To Eat A Lot More Without Becoming Obese

Unfashionable • 15 implied HN points • 14 Mar 24
🏥 Health & Wellness Metabolism
  1. Historically, people used to eat more without becoming obese, challenging the 'calories in, calories out' theory.
  2. Studies show that children in the past consumed significantly more calories than recommended today, even without modern concept of workouts.
  3. The Ray Peat community suggests that historically, people had faster metabolisms, which could explain the paradox of declining calorie intake and rising obesity rates.

048: Pantothenic Acid, Part 1 (What It Is and Why We Need It)

Harnessing the Power of Nutrients • 39 implied HN points • 19 Jun 19
🏥 Health & Wellness Metabolism
  1. Pantothenic acid deficiency is rare due to it not naturally occurring, but it plays crucial roles in metabolism, especially in burning fat and regulating metabolic pathways.
  2. Mothers transfer pantothenic acid to fetus and milk at their expense, highlighting its importance during adolescence and pregnancy.
  3. Food is preferred over supplements for vitamin B5 due to better absorption, and metabolic disorders may affect coenzyme A pool.

040: Why You Should Manage Your Thiamin Status and How to Do It

Harnessing the Power of Nutrients • 39 implied HN points • 14 Jan 18
🏥 Health & Wellness Metabolism
  1. Thiamin is crucial for energy metabolism and antioxidant defense; its deficiency can lead to neurological issues.
  2. Diets high in carbohydrates increase the need for thiamin, while certain foods like raw fish may contain thiamin antagonists.
  3. Thiamin deficiency can be caused by environmental exposure, so it's important to address potential sources and consider supplementation.

The Biochemistry of Vitamin K2

Harnessing the Power of Nutrients • 79 implied HN points • 28 Apr 13
🏥 Health & Wellness Metabolism
  1. Vitamin K2 plays a crucial role in carboxylating proteins to enable calcium binding, essential for various bodily functions.
  2. Vitamin K is vital for blood clotting as it helps in activating different clotting factors and is required for both procoagulants and anticoagulants.
  3. Osteocalcin, dependent on vitamin K, influences metabolic and hormonal health, and MGP regulated by vitamin K helps distribute calcium appropriately in the body.

038: Are We All Evolved to Eat High Protein?

Harnessing the Power of Nutrients • 19 implied HN points • 04 Oct 17
🏥 Health & Wellness Metabolism
  1. Excessive protein intake can be harmful, especially for individuals with rare genetic disorders affecting the breakdown of proteins.
  2. Consuming 4-5 times the recommended daily allowance of protein in athletic populations does not show negative effects.
  3. Understanding rare metabolic conditions related to protein metabolism can provide valuable insights for general health and wellness.

036: Is Insulin Really a Response to Blood Glucose?

Harnessing the Power of Nutrients • 19 implied HN points • 30 Jul 17
🏥 Health & Wellness Metabolism
  1. Insulin serves more functions beyond regulating blood glucose, such as affecting energy use and metabolic pathways.
  2. Insulin release is tied to total energy supply and energetic versatility, not solely blood glucose levels.
  3. Understanding the complex processes of insulin signaling sheds light on how different nutrients impact the body's energy metabolism.

035: The Biochemistry of Why Insulin Doesn’t Make You Fat

Harnessing the Power of Nutrients • 19 implied HN points • 22 Jul 17
🏥 Health & Wellness Metabolism
  1. Insulin doesn't directly make you fat; it's regulated by energy needs and availability at a biochemical level.
  2. All biochemical pathways, including the storage of fat by insulin, are influenced by cellular energy levels.
  3. Although insulin promotes fat storage, it also boosts glucose oxidation, leading to no net change in caloric balance.

033: Can Fat Fuel the Athlete?

Harnessing the Power of Nutrients • 19 implied HN points • 08 Jul 17
🏥 Health & Wellness Metabolism
  1. Different fuel sources are utilized at different rates during athletic activities, with fat providing a lot of energy but slowly, and glucose supplying energy rapidly.
  2. Studies have shown that for high-intensity activities, glucose is essential, whereas fat can be beneficial for longer duration, lower intensity exercises.
  3. Balancing fat and glucose intake is crucial for athletic performance, as each type of fuel has its own advantages and is used differently by the body during exercise.

021: When Fat People Can’t Get Fat Enough and Lean People Get Fat in All the Wrong Places

Harnessing the Power of Nutrients • 19 implied HN points • 08 Oct 16
🏥 Health & Wellness Metabolism
  1. Adipose tissue expansion is crucial for metabolic health and can be protected by surprising factors like inflammation.
  2. Visceral fat in the abdomen is protective as it drains into the liver directly, aiding in fat release.
  3. Accumulation of fat in the liver can occur even in lean individuals, compromising glycogen storage.

013: Wait a Second, Is Glycation Actually GOOD For You?

Harnessing the Power of Nutrients • 19 implied HN points • 09 Jun 16
🏥 Health & Wellness Metabolism
  1. Glycation may play essential roles in the body as part of a regulatory system and energy metabolism.
  2. Methylglyoxal produced during glycolysis can prevent dangerous buildups of compounds and help preserve glucose and convert fat to glucose.
  3. The rise of methylglyoxal during carbohydrate restriction is a stress response that should not be constantly activated.

Saturated Fat Does a Body Good

Harnessing the Power of Nutrients • 19 implied HN points • 22 May 16
🏥 Health & Wellness Metabolism
  1. Saturated fat is found in specific foods and not just in animal foods. Coconut is a rich source of saturated fat.
  2. Saturated fats are essential for membranes and proteins in the body. They play a crucial role in maintaining health.
  3. Certain saturated fats like MCTs and butyrate support energy metabolism and intestinal health. Consuming necessary fats in the diet may help spare the body from having to produce them.

Where Do Most AGEs Come From? O Glycation, How Thy Name Hast Deceived Me!

Harnessing the Power of Nutrients • 39 implied HN points • 07 Oct 11
🏥 Health & Wellness Metabolism
  1. AGEs are mostly formed from dicarbonyls, which are much more reactive than glucose and come from broken pieces of glucose, protein, and fat.
  2. Dietary AGEs are unlikely to significantly contribute to the pool of AGEs circulating in our bodies at any given moment as they are absorbed and excreted quickly.
  3. Most AGEs in our bodies are likely formed inside our cells, emphasizing the importance of cellular processes and defense mechanisms in handling AGEs.

We Really Can Make Glucose From Fatty Acids After All! O Textbook, How Thy Biochemistry Hast Deceived Me!

Harnessing the Power of Nutrients • 19 implied HN points • 07 Jan 12
🔬 Science Metabolism
  1. Biochemistry textbooks may claim that animals cannot convert fatty acids to glucose, but evidence suggests that it is possible under certain conditions.
  2. Acetate from fatty acids can be converted to glucose in a process involving ketogenesis, particularly when high levels of fatty acids flood the liver.
  3. Insulin plays a role in regulating the conversion of fatty acids to glucose by influencing enzyme production, demonstrating a complex network of reactions in the body.

Some Things I Like About “The New Evolution Diet”

Harnessing the Power of Nutrients • 19 implied HN points • 05 Feb 11
🏥 Health & Wellness Metabolism
  1. Intermittent fasting can potentially lengthen life, prevent degenerative diseases, offer dietary flexibility, and provide spiritual growth.
  2. Avoiding snacking, having three meals a day, and exercising in a fasted state can be extremely helpful for improving health and overcoming sleeping issues.
  3. High-intensity interval training, short bursts of exercise, and strength training can be effective for fitness and are backed by research, while calorie counting may not be necessary for a healthy diet.

Cholesterol Is Necessary for Digestion — Cholesterol Is a Precursor to Bile Acids

Harnessing the Power of Nutrients • 19 implied HN points • 27 Dec 08
🏥 Health & Wellness Metabolism
  1. Cholesterol is essential for digestion as it is used to create bile acids, which help digest fats.
  2. Bile acids act as emulsifying agents that mix fats with water in the digestive system, aiding in fat breakdown by water-soluble enzymes.
  3. Bile acids are converted to bile salts, which are more effective at mixing fats with water and are stored in the gall bladder for future use in digestion.

The Role of Microbiome in Disease Prevention ( Part 6.1/11)

Gutsphere - Your Ultimate Guide to Optimal Gut Health • 0 implied HN points • 15 Jan 24
🏥 Health & Wellness Metabolism
  1. A healthy gut microbiome helps regulate the immune system, reducing the risk of autoimmune diseases and enhancing the body's ability to fight infections.
  2. Balanced gut microbiota can help regulate inflammation, preventing diseases like arthritis, heart disease, and Alzheimer's.
  3. The gut microbiome influences metabolic health, reducing the risk of conditions such as obesity and type 2 diabetes in older adults.

Glycolymericks

The Science Monologue • 0 implied HN points • 17 Mar 23
🔬 Science Metabolism
  1. Enzymes play crucial roles in converting sugar into energy
  2. Hexokinase, Phosphoglucose isomerase, and Phosphofructokinase-1 are key enzymes in the process
  3. The glycolysis pathway involves multiple steps and enzymes to produce ATP