The hottest Metabolism Substack posts right now

And their main takeaways
Category
Top Science Topics

Current Beliefs, Suspicions and Confusions

The Heart Attack Diet • 99 implied HN points • 18 Feb 24
🏥 Health & Wellness Diet Metabolism Nutrition Weight management
  1. Man's natural state includes unconscious weight control and ample energy; modern lifestyles may derail this.
  2. Avoiding polyunsaturated fats and embracing natural foods like animal fats, salt, and moderate carbohydrates may be beneficial.
  3. Experimentation is key to understanding personal health; questions about metabolism, sulphite intolerance, and weight set-points remain.

One Year of the Heart Attack Diet II: Metabolism

The Heart Attack Diet • 119 implied HN points • 15 Jan 24
🏥 Health & Wellness Metabolism Weight Loss Nutrition Medical Advice Physical health
  1. Metabolic issues like hypothyroidism can have symptoms that doctors may label as Chronic Fatigue Syndrome, Fibromyalgia, or Major Depression. It's essential to explore treatment options that work for you.
  2. Diet changes, like cutting out polyunsaturated fats (PUFAs), may have a significant impact on metabolism and overall health. Consider avoiding PUFAs for potential improvements.
  3. It's crucial to be mindful of the impact of certain foods, like peanuts or palm oil, on metabolism. Forswearing polyunsaturated fats is advised for better health outcomes.

Bigger Livers?

Rough Diamonds • 21 implied HN points • 08 Nov 24
🏥 Health & Wellness Nutrition Athletic performance Metabolism
  1. Bigger athletes tend to have larger livers, and this contributes to their higher resting metabolic rates. This means they burn more energy even when not exercising, allowing them to eat more without gaining weight.
  2. Eating a higher-protein diet appears to promote liver growth. This suggests that if you want a bigger liver, increasing your protein intake along with exercise might help.
  3. Some methods to artificially increase liver size can lead to serious health issues, like cancer. It's better to focus on safe and natural ways to promote liver health, such as diet and exercise.

Confounded! PUFAs/Protein is Not The Answer

The Heart Attack Diet • 139 implied HN points • 08 Dec 23
🏥 Health & Wellness Diet Weight Metabolism Nutrition Empiricism
  1. The author is reevaluating their beliefs about the impact of PUFAs and protein on weight gain based on personal experiences and observations.
  2. The author is considering the concept of a weight-homeostat and the potential factors influencing metabolism and weight regulation.
  3. The author emphasizes the importance of empirical evidence and being open to adjusting beliefs based on new information and outcomes from experiments.

On The Need for a New Theory

The Heart Attack Diet • 159 implied HN points • 13 Nov 23
🏥 Health & Wellness Holistic health Nutrition Weight Loss Metabolism Well-being
  1. PUFAs are believed to be the root of obesity and metabolic health issues, but the direct evidence does not fully support this theory.
  2. A new theory is needed to explain weight loss and metabolic changes that go beyond solely cutting out PUFAs.
  3. Protein restriction may play a crucial role in weight loss and metabolic health, and could have a significant impact on dietary success.
Get a weekly roundup of the best Substack posts, by hacker news affinity:

Chapter 25: Science of Nutrition in Modern Health- Part 1

Spyderdoc Newsletter • 19 implied HN points • 09 Nov 24
🏥 Health & Wellness Nutrition Metabolism Hormones Diet Food Science
  1. Our bodies need food for survival, but it's important to choose the right foods to stay healthy. Understanding what we eat helps us make better choices for longevity.
  2. Hormones like ghrelin and leptin control our hunger and fullness. These hormones play a big role in how much we eat and can affect our weight.
  3. The way we process food has changed a lot over time. Today, many people eat more sugars and processed foods, leading to overeating and weight gain. We need to be mindful of our eating habits and try to eat healthier.

Friday Q&A: Diet Coke; Stomach Woes; Strength Training for Beginners; & Finding the Right Doctor for Menopause

Are You Okay? • 219 implied HN points • 03 Mar 23
🏥 Health & Wellness Nutrition Fitness Supplements Metabolism
  1. Consuming Diet Coke daily doesn't completely negate healthy eating habits, but it's worth considering the potential downsides such as caffeine content and artificial sweeteners.
  2. Individual responses to gas, bloating, and irregular bowel movements can vary, and there isn't one-size-fits-all advice for using probiotics to address these issues.
  3. Health is about balancing risks and rewards, and making choices that work best for your body and well-being, whether it's enjoying certain habits or deciding to make changes for better health.

Xmas Mom Test: Conclusions and Mysteries

The Heart Attack Diet • 99 implied HN points • 19 Jan 24
🏥 Health & Wellness Weight management Metabolism Nutrition Thyroid Health Mysteries
  1. The author believes that giving up PUFAs has had a positive impact on their metabolism and weight control.
  2. There is a pattern of weight changes and thyroid issues, with different dietary interventions affecting these aspects.
  3. Several mysteries remain, such as the initial cause of the curse, the role of different dietary components, and the effects of various interventions on metabolism and weight.

Some Successful Predictions of the Old Theory

The Heart Attack Diet • 139 implied HN points • 15 Nov 23
🏥 Health & Wellness Diet Weight Loss Chronic Fatigue Metabolism Nutrition
  1. Eating too much polyunsaturated fats (PUFAs) can clog your metabolism and lead to weight gain, tiredness, and other health issues.
  2. Avoiding PUFAs and sulfites can lead to improvements in energy levels and well-being.
  3. Old theories about diet and metabolism may help explain personal experiences, but new information and adjustments to these theories may be necessary over time.

Questions on Vitamin D, Fatty Liver, HbA1c vs CGM, Turmeric and Testosterone, Fasting, and B6 Markers

Harnessing the Power of Nutrients • 519 implied HN points • 24 Jul 22
🏥 Health & Wellness Nutrition Metabolism Supplementation Fasting
  1. Vitamin D activity may be better understood by measuring both 25(OH)D and 1,25(OH)2D due to their different strengths in activating the VDR.
  2. Fatty liver reversal progress can be seen in weeks with effective approaches, but the timeline varies based on individual factors.
  3. Prefer CGM results over HbA1c to assess diabetic status due to confounding factors affecting HbA1c accuracy.

Accidental Lipostat Test: Interim Results

The Heart Attack Diet • 79 implied HN points • 02 Feb 24
🏥 Health & Wellness Weight management Metabolism Nutrition Thyroid Health
  1. Your body's weight is controlled by a homeostatic system that adjusts your hunger based on your actions, leading to a gradual return to your set point weight.
  2. Monitoring and adjusting thyroid medication dosage can have a significant impact on energy levels and overall well-being.
  3. Eliminating certain dietary components, like polyunsaturated fats, may positively influence health and weight management over time.

Xmas Mom Test

The Heart Attack Diet • 99 implied HN points • 21 Dec 23
🏥 Health & Wellness Nutrition Weight Loss Self-experimentation Metabolism
  1. The author is facing a challenging 'Xmas Mom Test' where they expect to overeat while at home with their family, putting their weight loss theories to the ultimate test.
  2. Despite having various theories about weight loss and thyroid function, the author is unsure of what will happen during the test, highlighting the complexity of the human body's response to different diets.
  3. The author will observe trends in weight gain, appetite changes, and thyroid dose during the test, aiming to understand the impact of different dietary factors on their body's homeostasis.

Masterclass With Masterjohn: Energy Metabolism

Harnessing the Power of Nutrients • 519 implied HN points • 02 Jun 22
🏥 Health & Wellness Nutrition Metabolism Energy
  1. The Masterclass With Masterjohn on Energy Metabolism is a course with 39 lessons focusing on how our bodies burn carbohydrate and fat for fuel.
  2. The course covers essential concepts like thermodynamics, the role of enzymes in controlling reactions inside our bodies, and the use of citric acid cycle and electron transport chain to produce ATP.
  3. Lessons also delve into interesting topics like the regulation of energy metabolism, the production and utilization of ketones, and the historical origins of the ketogenic diet for treating epilepsy.

Fuel-Partitioning causes Obesity

Experimental Fat Loss • 169 implied HN points • 14 Jan 24
🏥 Health & Wellness Nutrition Weight Loss Fitness Metabolism Diet
  1. Mainstream CICO/EBM and Fuel Partitioning/low-carb are two paradigms about what causes obesity.
  2. CICO views calories as the cause of fat gain, while Fuel Partitioning sees excess calories as a result of other issues.
  3. CICO doesn't work for everyone, and there are diets like low-carb or keto that work better for some due to Fuel Partitioning.

Torricelli's Law for Fat Loss

Experimental Fat Loss • 127 implied HN points • 10 Mar 24
🏥 Health & Wellness Weight Loss Metabolism Diet Sleep Predictions
  1. Torricelli's Law for Fat Loss explains how weight loss can slow down as you approach your normal weight, similar to a bucket draining liquid with decreasing speed.
  2. Weight loss projections can be influenced by dietary changes and external factors, like daylight savings time affecting circadian rhythms and potentially affecting weight loss plateaus.
  3. Testing multiple weight loss projections, such as following a fitted curve and intuition-based predictions, can help in anticipating weight loss outcomes and adjusting dietary strategies.

Adding An Epicycle

The Heart Attack Diet • 99 implied HN points • 17 Nov 23
🏥 Health & Wellness Nutrition Biochemistry Metabolism Weight management
  1. Ancient theories added epicycles to make them work better, until Newton revealed the System of the World that was good enough.
  2. Epicycles in theories should not be added carelessly but should aim to explain data in a simpler way than the theory itself.
  3. Excess protein consumption beyond what the body needs for repair may interfere with the ability to process polyunsaturated fats for fuel.

ex150-9 review: Down 4lbs, broke through 220lbs

Experimental Fat Loss • 106 implied HN points • 18 Mar 24
🏥 Health & Wellness Weight Loss Nutrition Fitness Metabolism Healthy Eating
  1. Decision-making dilemma: stick to what works or explore new options. It's tricky to find the balance.
  2. Balancing exploitation and exploration in weight loss experiments is key to progress. Trying new things can build confidence, but sticking to what's known to work is crucial for consistent results.
  3. It's important to evaluate the success of experiments and prioritize proven methods. Understanding mechanisms behind weight loss can lead to more effective strategies.

Accidentally Testing the Lipostat Idea

The Heart Attack Diet • 59 implied HN points • 28 Jan 24
🏥 Health & Wellness Weight management Nutrition Metabolism
  1. Weight stability around 95kg for 8 months indicates a possible fixed fat level homeostat, suggesting weight may not rise above 95kg if left undisturbed.
  2. Following a diet based on whole foods suitable for English-Irish ancestry may align with natural metabolism processes and ancestral diets.
  3. Unexpected weight fluctuations due to excessive alcohol and overeating might be temporary noise and may return to normal levels in a few days, shedding light on conflicting theories about weight management.

ex150ish-4: Second Week

The Heart Attack Diet • 79 implied HN points • 11 Nov 23
🏥 Health & Wellness Nutrition Weight Loss Metabolism Diet Well-being
  1. Experiencing a rapid and noticeable weight loss during illness can be linked to the body's innate mechanisms prioritizing burning stored energy reserves over intake.
  2. The interplay between Branched Chain Amino Acids (BCAAs) and Polyunsaturated Fatty Acids (PUFAs) may impact metabolism and fat burning, potentially influencing appetite and weight.
  3. Consistent adjustments in diet composition, such as controlling BCAA levels and PUFA consumption, can play a role in weight management and overall well-being.

Reversing obesity != getting shredded

Experimental Fat Loss • 141 implied HN points • 21 Oct 23
🏥 Health & Wellness Obesity Metabolism Diet Nutrition Fitness
  1. Reversing obesity is not the same as achieving a shredded body like bodybuilders do.
  2. Starving yourself to extreme levels, like bodybuilders do, is not a sustainable or healthy method to reverse obesity.
  3. Using a strategy meant for bodybuilders, such as extreme dieting, to reverse obesity can be detrimental to your health in the long run.

Seed Oils explain the 8 Mysteries of Obesity

Experimental Fat Loss • 176 implied HN points • 22 Jul 23
🏥 Health & Wellness Obesity Nutrition Metabolism Diet Wellness
  1. Obesity is caused by long-term dysfunction of mitochondrial energy metabolism, mainly due to changes in food intake starting in the late 1800s and increased seed oil consumption since the 1930s and 1970s.
  2. The drastic increase in obesity rates since the mid-1970s can be attributed to the rise in seed oil consumption, such as the introduction of canola oil in the 1970s.
  3. The ongoing obesity crisis, even since 2010, has seen a massive increase due to a 50% rise in seed oil consumption like soybean oil.

Masterclass With Masterjohn: The Antioxidant System

Harnessing the Power of Nutrients • 279 implied HN points • 27 May 22
🏥 Health & Wellness Antioxidants Nutrition Metabolism Disease Prevention Wellness
  1. Antioxidants play a vital role in supporting our health by regulating energy metabolism, boosting the immune system, and aiding in exercise recovery, but can also contribute to health issues in excess.
  2. A balanced diet rich in nutrients like protein, fats, carbohydrates, vitamins, and minerals is essential for nourishing the antioxidant system.
  3. Understanding how the antioxidant system works is crucial for harnessing its benefits to support overall health and well-being.

Mom Test : Confusion

The Heart Attack Diet • 59 implied HN points • 28 Oct 23
🏥 Health & Wellness Nutrition Metabolism Weight Appetite Symptoms
  1. Weight changes can be confusing, especially when appetite and metabolism seem to be inconsistent.
  2. Cravings, like for baked potatoes, may not align with typical hunger or calorie needs, suggesting complex relationships between food and body signals.
  3. Health symptoms and weight fluctuations can puzzle, leaving individuals uncertain about their body's needs and responses.

Back to the Heart Attack Diet

The Heart Attack Diet • 59 implied HN points • 28 Jul 23
🏥 Health & Wellness Diet Weight Loss Metabolism Carbohydrates Alcohol
  1. The author experimented with different diets and observed a notable difference in how their body reacted to various types of food, indicating a potential issue with carbohydrate metabolism.
  2. Avoiding certain substances like PUFAs and sulphites, while consuming normal foods ad lib, seemed to aid in weight loss and maintenance effortlessly.
  3. The author's experience suggests that certain dietary restrictions and nutritional adjustments can have a significant impact on overall well-being, showcasing the importance of investigating individual metabolic responses to food.

Calories In, Calories Out

The Heart Attack Diet • 59 implied HN points • 09 Aug 23
🏥 Health & Wellness Nutrition Weight management Obesity Metabolism Appetite
  1. Calories In, Calories Out concept is often misunderstood. It's about the balance of calories consumed and calories burned.
  2. Obesity can be a complex issue influenced by various factors like appetite and metabolism. Some individuals struggle with constant hunger which leads to overeating.
  3. Understanding the reasons behind abnormal eating patterns and appetite can help in addressing obesity and finding solutions.

The Mysterious Case of Outlier 17

Experimental Fat Loss • 106 implied HN points • 07 Oct 23
🏥 Health & Wellness Weight Loss Diet Nutrition Metabolism
  1. Outlier 17 lost a significant amount of weight on the Half-Tato diet, which was only 50% potatoes and 50% regular food, with the main focus on how her approach ties into eliminating PUFAs, limiting protein intake, and focusing on a specific macronutrient.
  2. The Half-Tato diet study compared to other experiments led to observations that avoiding PUFAs, keeping protein intake low, and following a specific macro balance might contribute significantly to weight loss.
  3. Outlier 17's success might be due to factors like avoidance of PUFAs, low protein intake, and focus on a specific macro balance, indicating potential keys to effective weight loss.

Not losing fat on Keto/Carnivore? Try eating less protein.

Experimental Fat Loss • 141 implied HN points • 27 May 23
🏥 Health & Wellness Nutrition Weight Loss Metabolism Diet Medical Research
  1. Eating high protein might hinder fat loss on Keto/Carnivore diets; consider reducing protein intake.
  2. Popular Keto/Carnivore diets emphasize high protein, but excessive protein intake may not be suitable for everyone.
  3. Moderating protein intake and focusing on adequate fat consumption is essential for maintaining a balanced diet on Keto/Carnivore.

Mom Test: Mixed Results

The Heart Attack Diet • 39 implied HN points • 14 Oct 23
🏥 Health & Wellness Metabolism Diet Nutrition
  1. Recent weight gain of over 2kg in three weeks was the fastest rate ever, mostly due to overfeeding at home.
  2. The author's metabolism is slowly repairing itself, with normal thyroid health and potential impact from avoiding processed food.
  3. The author highlights the complex relationship between appetite, body fat percentage, and weight fluctuations based on different dietary approaches.

Results Graph

The Heart Attack Diet • 39 implied HN points • 05 Aug 23
🏥 Health & Wellness Weight Loss Diet Metabolism Nutrition
  1. The author created a graph displaying their weight fluctuations over time, highlighting a period of weight gain and subsequent weight loss.
  2. The data suggests that changes in diet rules, like eliminating sulphites and participating in specific exercises, influenced the author's weight trends.
  3. The graph analysis led the author to question the impact of different diet components, metabolic changes, and adjustments in medication on their weight and overall health.

Mom Test: Week One

The Heart Attack Diet • 39 implied HN points • 26 Sep 23
🏥 Health & Wellness Chronic Fatigue Metabolism Thyroid Health
  1. Experiencing chronic fatigue can make everyday tasks feel like a challenge, and it can be influenced by factors like diet and metabolism.
  2. Monitoring thyroid levels and adjusting medication can help manage symptoms like feeling excessively hot or cold.
  3. Changes in diet, especially a shift towards more carbohydrates, can impact energy levels and overall well-being.

Kraft test results: still insulin resistant

Experimental Fat Loss • 77 implied HN points • 30 Aug 23
🏥 Health & Wellness Nutrition Fitness Insulin Metabolism
  1. Insulin resistance can exist with normal glucose levels, especially after years on a ketogenic diet.
  2. Measuring fasting insulin levels can be a better indicator of insulin resistance than glucose levels.
  3. The Kraft test, which measures insulin response over time after a meal, can provide more insights into metabolic health than traditional glucose tests.

Biological Clocks, Cancer-Stopping Ketones, and How Our Bodies Get Fuel

coreygarvey • 79 implied HN points • 28 Jul 22
🏥 Health & Wellness Nutrition Fitness Research Metabolism Diet
  1. Research suggests that Metformin, a drug for diabetics, may increase lifespan for all individuals, including non-diabetics.
  2. Understanding how different types of carbs impact the body can help in making informed dietary choices.
  3. Intermittent fasting can help regulate energy levels and prevent overeating, contributing to weight management.

What it's Like to Have a Homeostat

The Heart Attack Diet • 19 implied HN points • 02 Sep 23
🏥 Health & Wellness Weight management Physical activity Healthy Eating Body Image Metabolism
  1. Weight can be maintained consistently over time with a well-functioning homeostat, regardless of lifestyle or diet changes.
  2. Consistent physical activity and high calorie consumption did not impact the author's weight due to their stable homeostat.
  3. Even drastic changes like cycling across a country and significant weight loss were corrected quickly by the homeostat to maintain a stable weight.