The hottest Medical Research Substack posts right now

And their main takeaways
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Top Health Politics Topics

Contra the ACMG on Polygenic Embryo Screening

Parrhesia β€’ 494 implied HN points β€’ 09 Mar 24
πŸ₯ Health & Wellness Genetics Ethics Medical Research Reproductive Rights
  1. Several scientists and professional organizations criticize polygenic embryo screening for polygenic disorders due to concerns like lack of validation and utility.
  2. The article argues that the recommendation against polygenic embryo screening is flawed because it doesn't compare the method to other acceptable alternatives like selection based on embryo morphology.
  3. The authors suggest that the critique against polygenic embryo screening lacks consideration of the ethical implications and does not provide a comprehensive cost-benefit analysis.

Do You Want Alex Joneses? Because That’s How You Get Alex Joneses

Singal-Minded β€’ 1623 implied HN points β€’ 15 Jun 23
πŸ₯ Health Politics Youth Gender Medicine Medical Research Misinformation
  1. The American Medical Association and Endocrine Society's statement on youth gender medicine is filled with misinformation and non sequiturs.
  2. There are concerns about the lack of rigorous research supporting the use of puberty blockers in youth gender medicine.
  3. Major medical organizations have been criticized for spreading misinformation on sensitive and politicized topics, leading to questions about their trustworthiness.

Low T and Me: Does Testosterone Therapy Increase Cardiovascular Risk?

The Skeptical Cardiologist β€’ 393 implied HN points β€’ 01 Jul 23
πŸ₯ Health & Wellness Medical Research Aging Therapies Cardiovascular Health Men's Health
  1. A recent study found no increase in cardiovascular risk with testosterone therapy for men with low T levels.
  2. Make sure to confirm low T levels before starting testosterone therapy.
  3. Weight loss and exercise can help alleviate symptoms related to low T without the use of testosterone therapy.

Could Ketamine Cure Tinnitus?

Ladyparts β€’ 579 implied HN points β€’ 27 Mar 23
πŸ₯ Health & Wellness Medical Research Mental health
  1. The author entered a clinical trial testing if ketamine could help with her tinnitus by staying immobile in an MRI for 90 minutes while tripping.
  2. The clinical trial for ketamine helping with tinnitus was spurred by an Instagram ad after two years of dealing with the ringing in the left ear.
  3. The study was designed by Dr. Diana Martinez and her research coordinator Alex Grassetti at the New York State Psychiatric Institute.

Long-COVID patients face treatment denials, skepticism from clinicians

HEALTH CARE un-covered β€’ 319 implied HN points β€’ 17 Nov 23
πŸ₯ Health & Wellness Chronic Illness Healthcare access Patient Advocacy Medical Research Public Health
  1. Long-COVID patients often struggle to be understood by doctors, facing skepticism about their symptoms. Many doctors don't have clear guidelines for treating long COVID, which can leave patients feeling frustrated and ignored.
  2. Symptoms of long COVID can be very varied and affect many parts of the body. People report issues like extreme fatigue, brain fog, and pain, which can significantly change their daily lives.
  3. The cost of treatment can be a huge burden for long COVID patients, especially in the U.S., where many face denied claims for necessary medications. This financial strain adds to the challenges they already face in managing their health.
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Do EpiPens Fail Higher-Weight Patients

Weight and Healthcare β€’ 359 implied HN points β€’ 21 Jun 23
πŸ₯ Health & Wellness Medical Research Medication Body Weight Healthcare access
  1. There is controversy around Epinephrine auto-injectors (EAIs) and higher-weight patients, with studies showing needle length inadequacy in penetrating muscle tissue in some individuals.
  2. Research indicates that proper needle length and low-pressure injection are crucial for effective EAI use in higher-weight individuals, with concerns about dose adequacy, especially in women with higher BMIs.
  3. To address EAI effectiveness in higher-weight patients, measuring skin-to-muscle depth for personalized needle selection, pushing firmly during injection, and advocating for more inclusive research are recommended.

Interview with Daniel MacArthur

The Good Science Project β€’ 26 implied HN points β€’ 02 Dec 24
πŸ”¬ Science Genomics Research Funding Medical Research Health Technology
  1. Daniel MacArthur is working on making genomic medicine fairer for all communities. His research includes studying genetic differences in underrepresented groups to improve health outcomes.
  2. He believes that funding for science needs to be more flexible and stable. This would allow researchers to take risks and pursue long-term projects without the constant pressure of grant deadlines.
  3. MacArthur thinks research organizations should be built specifically to support scientific work. Many current institutions are not designed for research, making it harder for scientists to succeed.

On the Origins of Type 1 Diabetes

Eat Shit and Prosper β€’ 439 implied HN points β€’ 30 Jun 23
πŸ₯ Health & Wellness Medical Research Autoimmune Disorders Public Health Epidemiology Disease Prevention
  1. Type 1 Diabetes (T1D) is an autoimmune disease where the immune system mistakenly attacks insulin-producing cells in the pancreas. It usually starts early in life and is linked to specific genetic and environmental factors.
  2. The incidence of T1D is rising globally, but it varies greatly by location and doesn't correlate strongly with typical factors like income or race. Scientists suspect that certain infections, especially with bacteria like Legionella, might trigger the disease in genetically susceptible individuals.
  3. Research suggests that exposure to Legionella bacteria might confuse the immune system, leading it to attack the pancreas. This means that cleaning up contaminated water systems could be key in reducing new T1D cases.

Was DoD the Managing Agency for Operation Warp Speed?

Who is Robert Malone β€’ 19 implied HN points β€’ 08 Dec 24
πŸ₯ Health Politics Vaccines Government Medical Research Public Health
  1. The Department of Defense (DoD) used a special contracting method called Other Transactional Authority (OTA) to quickly award contracts for the COVID-19 vaccine development. This approach allowed the government to bypass some traditional rules that slow down processes.
  2. There are claims that Pfizer isn't guilty of fraud, but rather provided what the U.S. Government requested under pressing timelines during the pandemic. The argument suggests that the government set the terms and conditions for the vaccine without ensuring thorough oversight.
  3. Because of how OTAs work, the contracts didn't require Pfizer to be as transparent with data, leading to concerns about the safety and effectiveness of the vaccines. This lack of stringent requirements may have contributed to public distrust.

Does this Study Really Say You Can't Be Fat and Fit?

Weight and Healthcare β€’ 459 implied HN points β€’ 17 Dec 22
πŸ₯ Health & Wellness Fitness Medical Research Weight Stigma Body positivity
  1. The study did not conclusively show that you can't be fat and fit, despite initial media headlines suggesting so
  2. Exercise provided health benefits for people of all sizes, indicating that activity can be beneficial regardless of body size
  3. The study's recommendation for weight loss as a primary health policy target lacked strong evidence and overlooked the impacts of weight stigma and weight cycling

Why do so many people have ultra-high levels of anti-spike antibodies years after receiving Covid mRNA jabs?

Unreported Truths β€’ 61 implied HN points β€’ 20 Dec 24
πŸ₯ Health Politics Vaccines Public Health Medical Research Disease Prevention Antibodies
  1. Many people are showing very high levels of anti-spike antibodies long after getting COVID mRNA vaccines. It's surprising to see that these levels can remain so elevated for years.
  2. The persistent presence of these antibodies raises concerns about potential long-term health effects. We really don't know yet what this means for people's health.
  3. There are important questions we need to answer about why some people have such high antibody levels. Understanding this is key to figuring out if there are any risks involved.

We’re Not Curing Cancer Here, Guys

Common Sense with Bari Weiss β€’ 204 implied HN points β€’ 22 Feb 24
πŸ₯ Health Politics Medical Research Fraud Data Transparency
  1. Transparency of raw data in medical research is crucial to uncovering fraud, as many papers only present summaries hiding potential malpractice.
  2. In medical research, the data presented in scientific papers is akin to a curated dating profile, showing only a portion of the actual work done.
  3. Calls for greater transparency, such as making all raw data available when publishing medical research, are crucial to combat fraud and encourage accountability in the field.

Stacy Skolnik: The Ginny Suite (excerpt)

Do Not Research β€’ 79 implied HN points β€’ 04 Mar 24
πŸ₯ Health Politics Health Conditions Medical Research Public Health
  1. Sunnyvale syndrome is a mysterious condition affecting thousands of women globally, with symptoms including amnesia, language loss, and more.
  2. Victims of Sunnyvale syndrome face challenges in getting proper diagnosis and recognition, often encountering skepticism and lack of information from medical authorities.
  3. Social media is amplifying conspiracy theories around conditions like Sunnyvale syndrome, fueling public anxiety and misinformation.

Bizarre hypervaccinator from Magdeburg receives 217 Covid jabs over 29 months, finally achieves antibody levels necessary to prevent infection

eugyppius: a plague chronicle β€’ 177 implied HN points β€’ 06 Mar 24
πŸ₯ Health & Wellness Vaccination Immune System Medical Research Conspiracy Theories Public Health
  1. A man from Magdeburg received 217 Covid vaccine jabs over 29 months, showing that achieving high antibody levels can prevent infection, with no negative health effects reported by researchers.
  2. The man's peculiar vaccination pattern raised questions about the investigation, incomplete jab data, and the feasibility of receiving so many doses without detection.
  3. The bizarre story prompts speculation about potential conspiracy theories regarding the man's extensive vaccination history and the challenges of verifying such a unique case.

#47 🍩 What the Health - A VC fund buys a hospital, Elon puts brain implants in humans & we're all eating millions of microplastics

What the Health?! β€’ 78 implied HN points β€’ 08 Feb 24
πŸ₯ Health & Wellness Health tech Digital Health Medical Research
  1. A VC fund bought a hospital, Elon Musk implanted brain chips in humans, and we are consuming millions of microplastics.
  2. Important updates in the health tech and innovation space, including funding reports, startup news, and noteworthy events.
  3. Exciting developments such as breakthroughs in diabetes treatment, presence of microplastics in protein sources, and advancements in cancer detection through blood tests.

URGENT: Authors of a big new paper on Covid's heart risks presented its results in a misleading way likely to scare people the paper itself shows are not in danger

Unreported Truths β€’ 64 implied HN points β€’ 11 Oct 24
πŸ₯ Health Politics Public Health Medical Research Pandemic response Misinformation
  1. A recent study found that most people who had Covid do not have an increased risk of heart problems long-term, contrary to scary headlines. It's important for people to have accurate information about their health risks.
  2. The reported increased risks mainly came from hospitalized Covid patients, who are already known to be at higher risk. Most people who were infected but did not need hospitalization had similar heart health to those who never contracted Covid.
  3. The misleading presentation of the study's findings could create unnecessary fear for those who had mild Covid cases. It’s crucial for people to understand their actual risk so they can manage their health appropriately.

Year In Review - Long Reads

ASeq Newsletter β€’ 7 implied HN points β€’ 18 Dec 24
πŸ•Ή Technology Genomics Sequencing Biotechnology Medical Research Health tech
  1. PacBio faced challenges in the stock market but still aims to provide high-quality clinical genomic sequencing. They are seen as a strong competitor in the long-read space despite financial struggles.
  2. Oxford Nanopore has been active in raising funds but has dealt with internal issues and departures of significant team members. Profitability remains an elusive goal for both them and PacBio.
  3. New competitors are emerging in the long-read sequencing market, including Roche and BGI, who are exploring nanopore sequencing technology. This could shake up the landscape for current players.

Thyroid Trouble

The Heart Attack Diet β€’ 119 implied HN points β€’ 16 Sep 23
πŸ₯ Health & Wellness Chronic Fatigue Medical Research Supplements Personal Health
  1. Thyroid issues can often be misdiagnosed or overlooked, leading to years of suffering without a clear answer.
  2. Alternative treatments or supplements may be worth considering for chronic conditions, even if traditional medical tests show normal results.
  3. Questioning traditional medical approaches and being open to unconventional solutions can sometimes lead to unexpected positive outcomes.

Gene Discovery in Early-Onset Breast Cancer

Holodoxa β€’ 99 implied HN points β€’ 28 Sep 23
πŸ₯ Health & Wellness Medical Research
  1. BRCA1 was a significant discovery in cancer genetics as it demonstrated the inheritance of cancer due to gene mutations passed down through generations.
  2. Competition and serendipity played roles in the discovery of BRCA1, showcasing the collaborative and competitive nature of scientific research.
  3. The race to identify, clone, and sequence BRCA1 involved notable scientists such as Mary-Claire King and Mark Skolnick, with Skolnick's team ultimately making the groundbreaking discovery.

Emergency Contraception and Higher Weight People

Weight and Healthcare β€’ 299 implied HN points β€’ 14 May 22
πŸ₯ Health & Wellness Reproductive Health Weight Stigma Inclusivity Medical Research
  1. Emergency contraception pills like Plan B may be less effective for higher-weight individuals, with higher weights potentially leading to decreased efficacy or even complete ineffectiveness above 176 pounds.
  2. Ulipristal acetate (Ella) pills, though requiring a prescription, have shown to be more effective than Levonorgestrel options for emergency contraception, especially for higher-weight individuals.
  3. Copper IUDs are the most effective emergency contraception method and show consistent efficacy regardless of weight, making them a recommended choice for higher-weight individuals.

The mRNA Revolution

Diane Francis β€’ 479 implied HN points β€’ 20 Dec 21
πŸ₯ Health Politics Vaccines COVID-19 Public Health Science Policy Medical Research
  1. The mRNA vaccines are an important breakthrough in fighting COVID-19 and other diseases. They help our bodies recognize and attack viruses more effectively.
  2. Despite concerns about variants like Omicron, the vaccines still offer protection. People are tired of restrictions, but the vaccines are a positive step forward.
  3. Scientists are continuing to innovate with mRNA technology. This could lead to even more health advancements in the future.

What miracle cures should we expect from cutting out seed oils?

Experimental Fat Loss β€’ 134 implied HN points β€’ 04 Nov 23
πŸ₯ Health & Wellness Nutrition Self-care Medical Research Mental health Physical health
  1. Cutting out seed oils can lead to improved skin health and reduced sunburn sensitivity.
  2. Seed oils can easily oxidize and negatively impact cell membranes, potentially causing health issues.
  3. The body can regenerate various cells impacted by seed oils within days to years, leading to potential health improvements over time.

Deliberate Dysentery

Asimov Press β€’ 96 implied HN points β€’ 21 Jan 24
πŸ₯ Health & Wellness Medical Research Ethics Safety Vaccines Infectious Diseases
  1. Human challenge trials have been used for centuries to deliberately infect individuals with pathogens for research purposes, such as testing vaccines and treatments.
  2. The rising popularity of challenge trials can be attributed to ethical reforms, development of solid challenge models, and the ability to safely and effectively test vaccines for various diseases.
  3. Challenge trials have drawbacks, including recruitment challenges, underpayment of participants, and difficulty in quantifying overall impact.

Miracle in Mainz

Diane Francis β€’ 679 implied HN points β€’ 05 Apr 21
πŸ₯ Health Politics Health Policy Medical Research Vaccination Public Health Biotechnology
  1. mRNA technology is changing medicine, promising to extend life and improve health. Vaccines for COVID-19 showed how effective this approach can be.
  2. BioNTech and Moderna rushed to create vaccines quickly, successfully using their mRNA methods. This faster way of making vaccines works better than older methods.
  3. There are plans to use mRNA technology for cancer vaccines in the near future. This could transform how we treat cancer and save many lives.

V-Safe Part 10: Federal Judge Orders CDC to Make Public 7.8 Million V-safe Free-Text Entries Within 12 Months

Injecting Freedom β€’ 91 implied HN points β€’ 11 Jan 24
πŸ₯ Health Politics Public Health COVID-19 vaccines Government transparency Medical Research
  1. Federal Judge orders CDC to release 7.8 million V-safe free-text entries for public access.
  2. The decision aims to promote transparency, trust, and accountability in government health data.
  3. Releasing the V-safe data is crucial for independent research and evaluating the safety and efficacy of COVID-19 vaccines.

Accelerating genetic design

The Century of Biology β€’ 272 implied HN points β€’ 26 Mar 23
πŸ”¬ Science Genetics Biotechnology Data Analysis AI Medical Research
  1. Multiple important technological paradigms are converging in the life sciences, impacting life on various scales.
  2. Synthetic biology focuses on designing new genetic circuits to program cells for new tasks.
  3. Using a platform like CLASSIC, genetic circuits can be systematically tested to learn composition-to-function relationships.

Not losing fat on Keto/Carnivore? Try eating less protein.

Experimental Fat Loss β€’ 141 implied HN points β€’ 27 May 23
πŸ₯ Health & Wellness Nutrition Weight Loss Metabolism Diet Medical Research
  1. Eating high protein might hinder fat loss on Keto/Carnivore diets; consider reducing protein intake.
  2. Popular Keto/Carnivore diets emphasize high protein, but excessive protein intake may not be suitable for everyone.
  3. Moderating protein intake and focusing on adequate fat consumption is essential for maintaining a balanced diet on Keto/Carnivore.

Could DMSO drops restore my vision?

Steve Kirsch's newsletter β€’ 19 implied HN points β€’ 13 Nov 24
πŸ₯ Health & Wellness Medical Research
  1. DMSO might help dissolve blood in the eye, but there's disagreement among doctors about its safety for the retina. Some say it could help, while others warn it might cause more harm than good.
  2. There's evidence that DMSO has been used safely in eye treatments in the past, with some patients seeing improvements, but the effects can vary greatly.
  3. Current treatments for blood in the eye usually include waiting for it to clear up naturally or surgery. DMSO could be a potential game changer, but more research is needed.

Tectonic Therapeutic: Protein Engineering and Fc-relaxin for Hypertension

Axial β€’ 7 implied HN points β€’ 31 Jan 25
πŸ₯ Health & Wellness Life Sciences Biotechnology Medical Research Drug Development
  1. Tectonic Therapeutic focuses on protein engineering to help treat hypertension. This means they are working on new medical treatments using proteins to effectively lower blood pressure.
  2. Axial invests in early-stage life sciences companies. They are particularly interested in supporting new ideas and inventions that can grow to make a big impact in healthcare.
  3. Support for inventors is a key part of Axial's mission. They aim to help those who are passionate about creating lasting solutions in the life sciences field.

Synthetic integrin antibodies discovered by yeast display reveal Ξ±V subunit pairing preferences with Ξ² subunits

Axial β€’ 7 implied HN points β€’ 31 Jan 25
πŸ”¬ Science Biotechnology Medical Research Pharmacology Cell Biology
  1. New antibodies were created that can specifically block integrins, which are important for cell functions like attachment and signaling. This may lead to better treatments for diseases.
  2. Researchers found that different Ξ² subunits bind preferentially to the Ξ±V subunit in integrins. Understanding these pairings helps explain how integrins work in the body.
  3. The antibodies developed through this study can directly compete with small molecules that normally bind to integrins. This opens the door for more precise therapies in the future.

Australian excess deaths are highly correlated with the number of booster vaccinations

Steve Kirsch's newsletter β€’ 10 implied HN points β€’ 05 Dec 24
πŸ₯ Health Politics Vaccinations Public Health Epidemiology Medical Research Policy Issues
  1. More booster shots lead to more excess deaths. It suggests a possible risk factor with the vaccines.
  2. There seems to be a link between more vaccines and increased COVID cases. This raises questions about their effectiveness.
  3. The study indicates serious concerns about the safety of vaccines, suggesting that some people may have been harmed significantly.

Is Ivermectin Literature Particularly Fraudulent?

Do Your Own Research β€’ 99 implied HN points β€’ 06 Mar 23
πŸ”¬ Science Medical Research Meta-analysis Data Analysis Research Integrity
  1. The ivermectin literature does not seem to be exceptionally fraudulent compared to other medical research.
  2. Researchers who criticized ivermectin studies have not made their data available for scrutiny.
  3. Concerns about the quality of research in the medical field in general are highlighted in this analysis.