The hottest Medical Research Substack posts right now

And their main takeaways
Category
Top Health Politics Topics

The Vaccine Revolution Will Now Be Televised

Viruses Must Die • 44 implied HN points • 19 Dec 25
🔬 Science Medical Research
  1. Ordinary brewer's yeast can be engineered into food-grade vaccines, and the experiments were reportedly doable on a simple household budget.
  2. This method could decentralize vaccine production so people or local microbreweries could make vaccines, potentially bypassing slow licensing and surviving even severe social disruptions.
  3. The target is viruses like polyomaviruses that cause serious illness (for example painful bladder disease in transplant patients), so edible vaccines could prevent a lot of suffering.

Could Ketamine Cure Tinnitus?

Ladyparts • 579 implied HN points • 27 Mar 23
🏥 Health & Wellness Medical Research
  1. The author entered a clinical trial testing if ketamine could help with her tinnitus by staying immobile in an MRI for 90 minutes while tripping.
  2. The clinical trial for ketamine helping with tinnitus was spurred by an Instagram ad after two years of dealing with the ringing in the left ear.
  3. The study was designed by Dr. Diana Martinez and her research coordinator Alex Grassetti at the New York State Psychiatric Institute.

Long-COVID patients face treatment denials, skepticism from clinicians

HEALTH CARE un-covered • 319 implied HN points • 17 Nov 23
🏥 Health & Wellness Medical Research
  1. Long-COVID patients often struggle to be understood by doctors, facing skepticism about their symptoms. Many doctors don't have clear guidelines for treating long COVID, which can leave patients feeling frustrated and ignored.
  2. Symptoms of long COVID can be very varied and affect many parts of the body. People report issues like extreme fatigue, brain fog, and pain, which can significantly change their daily lives.
  3. The cost of treatment can be a huge burden for long COVID patients, especially in the U.S., where many face denied claims for necessary medications. This financial strain adds to the challenges they already face in managing their health.

Medical Roundup #1

Don't Worry About the Vase • 1523 implied HN points • 16 Jan 24
🏥 Health & Wellness Medical Research
  1. Saving up medical and health related stories allows for better organization
  2. Vaccination developments include a new malaria vaccine, FDA approved vaccine for chikungunya, and a vaccine for cancer
  3. Challenges in the medical field include lack of funding delays, issues with the FDA, and concerns about the origins of Covid-19
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Do EpiPens Fail Higher-Weight Patients

Weight and Healthcare • 359 implied HN points • 21 Jun 23
🏥 Health & Wellness Medical Research
  1. There is controversy around Epinephrine auto-injectors (EAIs) and higher-weight patients, with studies showing needle length inadequacy in penetrating muscle tissue in some individuals.
  2. Research indicates that proper needle length and low-pressure injection are crucial for effective EAI use in higher-weight individuals, with concerns about dose adequacy, especially in women with higher BMIs.
  3. To address EAI effectiveness in higher-weight patients, measuring skin-to-muscle depth for personalized needle selection, pushing firmly during injection, and advocating for more inclusive research are recommended.

On the Origins of Type 1 Diabetes

Eat Shit and Prosper • 439 implied HN points • 30 Jun 23
🏥 Health & Wellness Medical Research
  1. Type 1 Diabetes (T1D) is an autoimmune disease where the immune system mistakenly attacks insulin-producing cells in the pancreas. It usually starts early in life and is linked to specific genetic and environmental factors.
  2. The incidence of T1D is rising globally, but it varies greatly by location and doesn't correlate strongly with typical factors like income or race. Scientists suspect that certain infections, especially with bacteria like Legionella, might trigger the disease in genetically susceptible individuals.
  3. Research suggests that exposure to Legionella bacteria might confuse the immune system, leading it to attack the pancreas. This means that cleaning up contaminated water systems could be key in reducing new T1D cases.

Do You Want Alex Joneses? Because That’s How You Get Alex Joneses

Singal-Minded • 1623 implied HN points • 15 Jun 23
🏥 Health Politics Medical Research
  1. The American Medical Association and Endocrine Society's statement on youth gender medicine is filled with misinformation and non sequiturs.
  2. There are concerns about the lack of rigorous research supporting the use of puberty blockers in youth gender medicine.
  3. Major medical organizations have been criticized for spreading misinformation on sensitive and politicized topics, leading to questions about their trustworthiness.

Does this Study Really Say You Can't Be Fat and Fit?

Weight and Healthcare • 459 implied HN points • 17 Dec 22
🏥 Health & Wellness Medical Research
  1. The study did not conclusively show that you can't be fat and fit, despite initial media headlines suggesting so
  2. Exercise provided health benefits for people of all sizes, indicating that activity can be beneficial regardless of body size
  3. The study's recommendation for weight loss as a primary health policy target lacked strong evidence and overlooked the impacts of weight stigma and weight cycling

Stories We'd Like to Publish (Part II)

Asimov Press • 290 implied HN points • 08 Jan 25
🔬 Science Medical Research
  1. Asimov Press is inviting writers to pitch stories about scientific progress. If you have an idea or interest in topics like biotechnology, they want to hear from you!
  2. They have released a long list of interesting story ideas, ranging from the history of common medicines to new discoveries in gene editing. Any writer can find a topic that resonates with them.
  3. Asimov Press aims to support writers through the entire publishing process. Accepted pitches will receive help with outlining, editing, and will be compensated for their work.

Stacy Skolnik: The Ginny Suite (excerpt)

Do Not Research • 79 implied HN points • 04 Mar 24
🏥 Health Politics Medical Research
  1. Sunnyvale syndrome is a mysterious condition affecting thousands of women globally, with symptoms including amnesia, language loss, and more.
  2. Victims of Sunnyvale syndrome face challenges in getting proper diagnosis and recognition, often encountering skepticism and lack of information from medical authorities.
  3. Social media is amplifying conspiracy theories around conditions like Sunnyvale syndrome, fueling public anxiety and misinformation.

Mouse Caviar

De Novo • 99 implied HN points • 04 Jul 25
🔬 Science Medical Research
  1. Researchers have found a way to produce mouse eggs from stem cells, even without ovarian cells. This could lead to advancements in egg production technology.
  2. The method shows that meiosis can occur in 2D cultures, making it easier to do research in the lab. However, the eggs produced currently can’t fully mature without ovarian support.
  3. This study challenges previous beliefs about the necessity of ovarian cells for early egg development, which opens up new avenues for understanding and improving in vitro reproduction.

New Orders from Trump on Health

Who is Robert Malone • 16 implied HN points • 20 Dec 25
🏥 Health Politics Medical Research
  1. The president designated illicit fentanyl as a Weapon of Mass Destruction. That label unlocks broader law enforcement, financial, intelligence, and potential military tools to disrupt production and trafficking.
  2. Major drugmakers agreed to Most‑Favored‑Nation pricing and to donate active pharmaceutical ingredients to a Strategic Reserve. Those steps aim to lower U.S. drug costs and strengthen supply chains to reduce reliance on foreign manufacturing.
  3. Medical marijuana is being fast‑tracked toward Schedule III and expanded research on CBD and cannabis is ordered. This will ease research barriers, likely increase medical access and commercial opportunities, but it does not federally legalize marijuana.

#47 🍩 What the Health - A VC fund buys a hospital, Elon puts brain implants in humans & we're all eating millions of microplastics

What the Health?! • 78 implied HN points • 08 Feb 24
🏥 Health & Wellness Medical Research
  1. A VC fund bought a hospital, Elon Musk implanted brain chips in humans, and we are consuming millions of microplastics.
  2. Important updates in the health tech and innovation space, including funding reports, startup news, and noteworthy events.
  3. Exciting developments such as breakthroughs in diabetes treatment, presence of microplastics in protein sources, and advancements in cancer detection through blood tests.

A Search for Sick Animals

Asimov Press • 186 implied HN points • 05 Feb 25
🔬 Science Medical Research
  1. Animal models are really important for studying diseases like Parkinson's because they can show how conditions develop and help test new treatments.
  2. Researchers have looked for animals with naturally occurring Parkinson's, but finding them is hard. A recent study claims to have found a monkey with the disease indicating there may be others we just haven't discovered yet.
  3. If scientists can identify more animals with Parkinson's, it could lead to better understanding and treatment options for humans. It's important to keep searching for these models.

Contra the ACMG on Polygenic Embryo Screening

Parrhesia • 494 implied HN points • 09 Mar 24
🏥 Health & Wellness Medical Research
  1. Several scientists and professional organizations criticize polygenic embryo screening for polygenic disorders due to concerns like lack of validation and utility.
  2. The article argues that the recommendation against polygenic embryo screening is flawed because it doesn't compare the method to other acceptable alternatives like selection based on embryo morphology.
  3. The authors suggest that the critique against polygenic embryo screening lacks consideration of the ethical implications and does not provide a comprehensive cost-benefit analysis.

Big Data, Small Payoff: Madrid Study Finds Pediatric mRNA Vaccine Benefits Thin—and Safety Questions Still Linger

Who is Robert Malone • 9 implied HN points • 31 Dec 25
🏥 Health Politics Medical Research
  1. mRNA COVID-19 vaccines cut hospitalizations by only a few cases per 100,000 children, with almost no measurable benefit in 6–11-year-olds and a modest reduction in 12–17-year-olds.
  2. Serious outcomes like hospitalizations, MIS‑C, and myocarditis were rare overall, and while heart inflammation was uncommon, it was not clearly lower in vaccinated adolescents.
  3. Because absolute benefits are tiny and uncertainty is wide, the findings support shifting away from universal pediatric vaccination toward individualized, risk‑based recommendations.

Pausing NIH study sections is going to be fine

Vinay Prasad's Observations and Thoughts • 157 implied HN points • 23 Jan 25
🏥 Health Politics Medical Research
  1. Pausing NIH study sections can help bring necessary changes. It's a good opportunity to rethink how research funding is distributed.
  2. Current funding processes tend to support more conventional ideas rather than groundbreaking ones. There needs to be a push for more innovative and transformative research.
  3. If cuts happen in research funding, especially for less impactful areas, it could lead to better use of public dollars. We need to focus on research that truly makes a difference.

Thyroid Trouble

The Heart Attack Diet • 119 implied HN points • 16 Sep 23
🏥 Health & Wellness Medical Research
  1. Thyroid issues can often be misdiagnosed or overlooked, leading to years of suffering without a clear answer.
  2. Alternative treatments or supplements may be worth considering for chronic conditions, even if traditional medical tests show normal results.
  3. Questioning traditional medical approaches and being open to unconventional solutions can sometimes lead to unexpected positive outcomes.

Rule Two: No Sulphites

The Heart Attack Diet • 119 implied HN points • 26 Jun 23
🏥 Health & Wellness Medical Research
  1. Alcohol intolerance can develop over time and be triggered by specific ingredients like sulphites.
  2. Sulphite allergy, though rare, can cause adverse reactions like headaches and nausea.
  3. Testing different drinks and ingredients can help identify and manage alcohol intolerance triggers.

Artificial intelligence and mRNA vaccines are not going to cure cancer

Vinay Prasad's Observations and Thoughts • 156 implied HN points • 22 Jan 25
🏥 Health Politics Medical Research
  1. Artificial intelligence and mRNA vaccines are not expected to cure cancer. Both technologies have limitations that make them less effective in treating this complex disease.
  2. Cancer therapeutic vaccines have been studied extensively, but only one has received FDA approval, and it shows only a slight benefit in survival. Overall, these vaccines often do not work as hoped.
  3. AI struggles to diagnose cancer accurately and often lacks the needed data to improve this. Simply detecting cancer is not enough; finding the right treatment for each specific case is much more complicated.

Gene Discovery in Early-Onset Breast Cancer

Holodoxa • 99 implied HN points • 28 Sep 23
🏥 Health & Wellness Medical Research
  1. BRCA1 was a significant discovery in cancer genetics as it demonstrated the inheritance of cancer due to gene mutations passed down through generations.
  2. Competition and serendipity played roles in the discovery of BRCA1, showcasing the collaborative and competitive nature of scientific research.
  3. The race to identify, clone, and sequence BRCA1 involved notable scientists such as Mary-Claire King and Mark Skolnick, with Skolnick's team ultimately making the groundbreaking discovery.

DNA Fragments as Vaccine Adjuvants

Who is Robert Malone • 12 implied HN points • 24 Nov 25
🔬 Science Medical Research
  1. DNA fragments used in vaccine production may pose risks if they integrate into human cells. This could affect how our cells produce proteins and replicate.
  2. Injecting 'naked' DNA or RNA can allow cells to take up these materials directly, which can be used for vaccine development.
  3. CpG sequences in DNA fragments can enhance immune responses and have been explored in various vaccines, but their presence in mRNA vaccines raises safety and patent concerns for companies like Pfizer.

Emergency Contraception and Higher Weight People

Weight and Healthcare • 299 implied HN points • 14 May 22
🏥 Health & Wellness Medical Research
  1. Emergency contraception pills like Plan B may be less effective for higher-weight individuals, with higher weights potentially leading to decreased efficacy or even complete ineffectiveness above 176 pounds.
  2. Ulipristal acetate (Ella) pills, though requiring a prescription, have shown to be more effective than Levonorgestrel options for emergency contraception, especially for higher-weight individuals.
  3. Copper IUDs are the most effective emergency contraception method and show consistent efficacy regardless of weight, making them a recommended choice for higher-weight individuals.

The mRNA Revolution

Diane Francis • 479 implied HN points • 20 Dec 21
🏥 Health Politics Medical Research
  1. The mRNA vaccines are an important breakthrough in fighting COVID-19 and other diseases. They help our bodies recognize and attack viruses more effectively.
  2. Despite concerns about variants like Omicron, the vaccines still offer protection. People are tired of restrictions, but the vaccines are a positive step forward.
  3. Scientists are continuing to innovate with mRNA technology. This could lead to even more health advancements in the future.

Repeated mRNA Covid jabs are linked to faster death from pancreatic cancer

Unreported Truths • 43 implied HN points • 07 Jul 25
🏥 Health Politics Medical Research
  1. Receiving three or more mRNA Covid vaccines is linked to shorter survival rates in pancreatic cancer patients. Those with more shots died faster than those with fewer shots.
  2. The study found changing levels of IgG4 antibodies in patients, which may weaken their immune response against cancer. This suggests the vaccines might change how the body fights tumors.
  3. Previous research indicated rising cancer death rates in Japan since the vaccine rollout. This study offers more detailed insights by tracking patients based on their vaccine status.

Bah Humbug: No Matter How Hard They Try, Masks Still Don't Work

Unmasked • 113 implied HN points • 24 Dec 24
🏥 Health Politics Medical Research
  1. Masks have been debated since the pandemic began, but many experts still believe they don't work effectively. This has led to ongoing discussions among people who support or oppose their use.
  2. Past studies attempting to prove the effectiveness of masks have often been criticized for their flaws and misleading results. This has caused skepticism about the reliability of mask research.
  3. Recent studies that promote mask-wearing continue to fuel the belief among some groups, but they are viewed by others as inaccurate or propaganda. This division highlights the ongoing controversy over mask mandates.

Miracle in Mainz

Diane Francis • 679 implied HN points • 05 Apr 21
🏥 Health Politics Medical Research
  1. mRNA technology is changing medicine, promising to extend life and improve health. Vaccines for COVID-19 showed how effective this approach can be.
  2. BioNTech and Moderna rushed to create vaccines quickly, successfully using their mRNA methods. This faster way of making vaccines works better than older methods.
  3. There are plans to use mRNA technology for cancer vaccines in the near future. This could transform how we treat cancer and save many lives.

Addressing Research Fraud

The Good Science Project • 89 implied HN points • 27 Jan 25
🔬 Science Medical Research
  1. The Good Science Project aims to help investigate research fraud and support whistleblowers. They want to make it easier for people to report misconduct in science.
  2. Research fraud is a common problem, with many scientists admitting to questionable practices. Reports suggest that a significant number of researchers have seen or engaged in misconduct.
  3. The project plans to provide legal and educational resources for those worried about speaking out against fraud. They want to empower more people to come forward about their concerns.

My revised $1M offer to Paul Offit

Steve Kirsch's newsletter • 5 implied HN points • 19 Dec 25
🏥 Health Politics Medical Research
  1. A $1 million challenge invites an expert to defend a JAMA study that claims mRNA vaccination did not increase 4-year all-cause mortality, with impartial judges to decide the winner.
  2. The critic argues the study is too confounded to draw reliable conclusions about non-COVID deaths because retrospective propensity-weighted cohorts (and 1:1 matching) cannot fully adjust for bias.
  3. The challenge is presented as educational and non-accusatory, aiming to clarify interpretation of published science, and it includes a prediction that the invited expert will likely decline.

Genesis Mission challenges for biotechnology

A Biologist's Guide to Life • 8 implied HN points • 03 Dec 25
🔬 Science Medical Research
  1. Automating research in high-security labs can make work safer and more efficient. This will help scientists handle dangerous pathogens without direct human contact, which is crucial for preventing accidents.
  2. There is a need for better tools in genetics, specifically for aligning and annotating DNA sequences. Modernizing these tools can lead to faster results and more discoveries in biology.
  3. Improving how quickly patients receive medical care is essential. By using AI to streamline processes and reduce paperwork, we can make healthcare more efficient and improve patient experiences.

We’re Not Curing Cancer Here, Guys

Common Sense with Bari Weiss • 204 implied HN points • 22 Feb 24
🏥 Health Politics Medical Research
  1. Transparency of raw data in medical research is crucial to uncovering fraud, as many papers only present summaries hiding potential malpractice.
  2. In medical research, the data presented in scientific papers is akin to a curated dating profile, showing only a portion of the actual work done.
  3. Calls for greater transparency, such as making all raw data available when publishing medical research, are crucial to combat fraud and encourage accountability in the field.

NBC Blasts Trump and Kennedy for Wanting to Conduct Vaccine-Autism Studies

Injecting Freedom • 84 implied HN points • 08 Dec 24
🏥 Health Politics Medical Research
  1. NBC criticized Trump and Kennedy for wanting to explore a possible link between vaccines and autism. They say it has been thoroughly studied and debunked, but some people think more research is needed.
  2. Many parents of autistic children believe vaccines might have caused their child's autism. However, there haven't been enough studies specifically on this issue to confirm or deny that link.
  3. Despite claims that vaccines don't cause autism, there’s a lack of solid studies backing it up. This raises questions about the safety of vaccines and other health concerns that parents have.

Bizarre hypervaccinator from Magdeburg receives 217 Covid jabs over 29 months, finally achieves antibody levels necessary to prevent infection

eugyppius: a plague chronicle • 177 implied HN points • 06 Mar 24
🏥 Health & Wellness Medical Research
  1. A man from Magdeburg received 217 Covid vaccine jabs over 29 months, showing that achieving high antibody levels can prevent infection, with no negative health effects reported by researchers.
  2. The man's peculiar vaccination pattern raised questions about the investigation, incomplete jab data, and the feasibility of receiving so many doses without detection.
  3. The bizarre story prompts speculation about potential conspiracy theories regarding the man's extensive vaccination history and the challenges of verifying such a unique case.

Former US Surgeon General is spreading misinformation again: The new BMJ study does NOT conflict with the HHS advice to avoid Tylenol

Steve Kirsch's newsletter • 6 implied HN points • 11 Nov 25
🏥 Health Politics Medical Research
  1. The recent BMJ study does not clearly link maternal use of Tylenol to autism or ADHD, but it highlights the studies' low reliability.
  2. There's a 25-35% increased risk of ADHD and autism from prenatal Tylenol exposure, which is concerning enough to warrant further research.
  3. It's important not to stop researching the potential risks of Tylenol during pregnancy, despite some claims encouraging otherwise.

Estrogen and Covid-19 Mortality

Ladyparts • 159 implied HN points • 19 May 22
🏥 Health & Wellness Medical Research
  1. Women prescribed hormone replacement within six months of Covid-19 infection had lower mortality rates.
  2. Estrogen treatment post-Covid lowered mortality risk in women with asthma.
  3. There is a notable lack of awareness among medical professionals regarding the protective benefits of estrogen for women's health issues.