The hottest Research Substack posts right now

And their main takeaways
Category
Top Health Politics Topics

The Bear Cave #307

The Bear Cave โ€ข 489 implied HN points โ€ข 04 Jan 26
๐Ÿ’ฐ Finance Research
  1. New Era Energy & Digital faces a New Mexico lawsuit that could block its data-center plans, and there are allegations the company used paid stock promotion.
  2. Thirteen deep-dive investigations published in 2025 underperformed the market on average, falling about 8.5% from publication while the S&P 500 rose about 9.9%.
  3. Several CEOs and senior executives recently resigned or were terminated, and multiple companies disclosed paid stock-promotion campaigns, highlighting governance and market-risk concerns among smaller public firms.

Human Nature, Nick Fuentes, Education Exchange

Rob Henderson's Newsletter โ€ข 984 implied HN points โ€ข 11 Dec 25
๐ŸšŒ Education Research
  1. Humans are relatively monogamous compared with chimpanzees and gorillas, with an estimated monogamy rating around two-thirds.
  2. Mainstream media show ideological blindspots, so tools that compare coverage and highlight underreported stories can help readers spot bias and find missing reporting.
  3. Recent studies link social exposure, personality, and political beliefs: wealthy peopleโ€™s local exposure to poor neighbors can reduce their support for redistribution, personality traits predict everyday behaviors, and sizable minorities in parts of the Republican coalition hold distorted views of the Holocaust.

Condoleezza Rice: Pulling University Funding Threatens U.S. Tech Dominance

Big Technology โ€ข 4003 implied HN points โ€ข 21 Jul 25
๐Ÿ‡บ๐Ÿ‡ธ U.S. Politics Research
  1. Cutting university funding can hurt tech innovation in the U.S. Universities play a crucial role in research that leads to breakthroughs and advancements.
  2. The country doesn't have a backup plan if university research is reduced. Most fundamental research happens in universities, and without them, technological progress could stall.
  3. We need to value and support diverse education paths, including vocational training. Everyone should have the chance to pursue education, whether it's a degree or skilled trades.

Read Something Wonderful (about Biology)

Asimov Press โ€ข 1250 implied HN points โ€ข 20 Nov 25
๐Ÿ”ฌ Science Research
  1. Curation of essays is valuable because it leads readers to new ideas they might not discover on their own. It's like finding hidden gems on the internet.
  2. The curated list of biology essays is meant for leisurely reading and focuses on timeless insights instead of quick news, helping readers take their time to enjoy and understand the content.
  3. Exploring essays by different authors can expand your knowledge and perspective on biology, making it a rewarding experience to find writers whose work you love.
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A modern day witch trial

uTobian โ€ข 8667 implied HN points โ€ข 01 May 23
๐Ÿฅ Health & Wellness Research
  1. The study on autism prevalence and costs shows the rising financial burden of autism over the years.
  2. The model presented in the study reveals the alarming increase in autism rates, especially for certain demographics.
  3. The study highlights the shift in costs from parents to government as the first generation of autism epidemic children age, emphasizing the need for prevention strategies.

Real-time AI Voice Agents and Determinism Through Tool-Calling

Impertinent โ€ข 79 implied HN points โ€ข 06 Oct 24
๐Ÿ•น Technology Research
  1. Generative AI often faces uncertainty, but there may be ways to achieve reliable reasoning. It's exciting to learn that we can improve the predictability of AI outcomes.
  2. A big project in AI development can lead to many challenges and uncharted areas. Even if some efforts end in failure, it's important to find and build on the valuable lessons learned.
  3. Real-time AI voice agents have the potential to change how we interact with technology. This could make using AI smarter and more effective in our daily lives.

IVERMECTIN and CANCER, it has at least 15 anti-cancer mechanisms of action. Can Ivermectin Treat COVID-19 mRNA Vaccine Induced Turbo Cancers? - 9 Ivermectin papers reviewed

2nd Smartest Guy in the World โ€ข 4992 implied HN points โ€ข 08 Jan 24
๐Ÿฅ Health & Wellness Research
  1. Ivermectin has at least 15 anti-cancer mechanisms of action.
  2. Studies suggest Ivermectin can treat a variety of cancers.
  3. High doses of Ivermectin, possibly combined with Fenbendazole, may be beneficial for treating cancer.

Funding science is actually a badass thing to do

Experimental History โ€ข 9269 implied HN points โ€ข 18 Feb 25
๐Ÿ”ฌ Science Research
  1. Funding science is essential because it helps us gain knowledge, which is the key to improving our lives. Every advancement we've made comes from learning and understanding more about the world.
  2. We need to be careful not to fall into traps of thinking we can solve problems by reducing knowledge. Instead, we should focus on increasing our understanding to overcome challenges.
  3. Fixing the science funding system could be simple. For example, by avoiding payments to for-profit publishers and reducing unnecessary grant application processes, we can make better use of our resources and support innovative research.

MBTI, If You Want Me Back, You Need to Change Too

Granted โ€ข 8705 implied HN points โ€ข 05 Mar 23
๐Ÿ”ฌ Science Research
  1. Consider embracing the latest data to improve the theory by moving away from antiquated ideas and focusing on more reliable traits.
  2. Demand real evidence for efficacy by conducting randomized, controlled experiments to validate the benefits claimed by MBTI.
  3. Understand that many scientists have left MBTI due to concerns about its validity and its historical associations with racism and sexism.

The AI Nobels

Dana Blankenhorn: Facing the Future โ€ข 59 implied HN points โ€ข 09 Oct 24
๐Ÿ•น Technology Research
  1. Two major Nobel prizes were awarded to individuals working in AI, highlighting its importance and growth in science. Geoffrey Hinton won a physics prize for his work in machine learning.
  2. Current AI technology is still in the early stages and relies on brute force data processing instead of true creativity. The systems we have are not yet capable of real thinking like humans do.
  3. Exciting future developments in AI could come from modeling simpler brains, like that of a fruit fly. This may lead to more efficient AI software without requiring as much power.

Working memory: one of the most important things to understand about learning

The Bell Ringer โ€ข 519 implied HN points โ€ข 19 Jul 24
๐ŸšŒ Education Research
  1. Working memory is crucial for learning because it helps us hold and process information. Understanding how it works can improve teaching methods.
  2. Many teachers in the U.S. aren't trained on working memory, which limits their ability to support students effectively. Better training can help teachers use this knowledge in classrooms.
  3. Memorizing basic facts, like math facts, is important for building a strong foundation in learning. When students know these facts, they can focus on more complex problems.

Adam Kucharski: The Uncertain Science of Certainty

Ground Truths โ€ข 3718 implied HN points โ€ข 29 Jun 25
๐Ÿ”ฌ Science Research
  1. Science is about understanding uncertainty and the limits of what we know. It's important to recognize that truth can change as new evidence comes in.
  2. Different types of proof, such as randomized trials or natural experiments, all have their pros and cons. It's crucial to evaluate what type is best for the situation at hand.
  3. Repetition can affect our belief in something, even if it's not true. It's essential to stay open to different viewpoints and challenge our own beliefs.

Open Thread 390

Astral Codex Ten โ€ข 3372 implied HN points โ€ข 14 Jul 25
๐Ÿ”ฌ Science Research
  1. You can talk about anything you like in this open thread, ask questions, or share ideas. It's a great way to interact with others.
  2. There was a recent discussion about a math error in a simulation related to schizophrenia, showing the importance of accuracy in research.
  3. A user reported vision loss potentially linked to a probiotic, but many are skeptical. It's a reminder to approach health claims carefully and seek expert advice.

"The greatest fear among vaccinologists is the creation of a vaccine that is not only ineffective, but which exacerbates disease. Unfortunately, CoV vaccines have a history of enhancing disease..."

2nd Smartest Guy in the World โ€ข 3301 implied HN points โ€ข 23 Jan 24
๐Ÿฅ Health & Wellness Research
  1. Vaccines have a history of enhancing disease, rather than just being ineffective.
  2. Research studies have shown severe side effects in animals from certain vaccines.
  3. The emergency authorization of vaccines bypassed normal trial processes, raising concerns.

Open Thread 389

Astral Codex Ten โ€ข 3303 implied HN points โ€ข 07 Jul 25
๐ŸŽญ๏ธ Culture Research
  1. This is an open thread where anyone can talk about anything or ask questions. It's a great space for discussion and sharing ideas.
  2. There are highlights about various topics in the comments, like family size's impact on motherhood and discussions on testosterone. They spark interesting conversations.
  3. Thereโ€™s a new post for subscribers discussing how AI is used in research. It's a mix of useful and tricky information that needs careful thought.

How the Businessmen Lost the AI Race

The Algorithmic Bridge โ€ข 254 implied HN points โ€ข 21 Jan 26
๐Ÿ•น Technology Research
  1. AI leadership is shifting from business executives to scientists, changing who leads the field. This means researchers are increasingly setting priorities and steering public debate.
  2. The tone of AI conversations has moved toward long-term, scientific questions like what happens after AGI, rather than just product or profit talk. Panels and forums now emphasize technical and existential concerns.
  3. Who shows up matters: prominent researchers like Demis Hassabis and Dario Amodei are center stage at Davos while some big-name CEOs are absent. That attendance pattern signals scientists are shaping the industryโ€™s narrative and agenda.

Breaking echo chambers, white-label resources, and this monthโ€™s top science picks

Your Local Epidemiologist โ€ข 625 implied HN points โ€ข 12 Dec 25
๐Ÿฅ Health Politics Research
  1. Thereโ€™s growing investment in infrastructure to connect institutions, experts, and the public for better health communication. A new social-media program has launched with support from parent advocates.
  2. White-label scientific briefs are now available so people can share evidence with decision-makers under their own branding. The latest downloadable guide focuses on community water fluoridation.
  3. Five recent studies were highlighted, including a rise in parents refusing newborn vitamin K shots and notable oral GLP-1 trial results. These findings are being tracked because they could affect clinical choices and public health messaging.

Does Social and Emotional Learning (SEL) improve academic outcomes?

The Science of Learning โ€ข 219 implied HN points โ€ข 12 Aug 24
๐ŸšŒ Education Research
  1. Social and Emotional Learning (SEL) helps students with their emotions and relationships but it's unclear if it boosts academic performance. Some studies show positive impacts, while others do not.
  2. Different schools use SEL in varied ways, making it tough to gauge its true effectiveness. This inconsistency leads to mixed results in research about SEL's benefits.
  3. There's no strong evidence that SEL reduces the achievement gap or promotes equity in education. More focused studies are needed to really understand SEL's long-term effects.

Icesteading: Executive Summary

Transhuman Axiology โ€ข 178 implied HN points โ€ข 11 Sep 24
๐Ÿ”ฌ Science Research
  1. Icesteading is the idea of creating colonies on artificially insulated icebergs in warm ocean waters. These 'ice-islands' could serve as places for living, working, or even launching space missions.
  2. The insulation around these icebergs can make them last for decades or even centuries before melting. This involves using materials like air or foam to keep the ice from warming up too fast.
  3. Building on these ice-islands avoids the legal and political issues on land. They offer more freedom and the chance to create underground spaces, making them a unique alternative to traditional islands.

Using AI Right Now: A Quick Guide

One Useful Thing โ€ข 3429 implied HN points โ€ข 23 Jun 25
๐Ÿ•น Technology Research
  1. For most people wanting to use AI effectively, stick with one of three top systems: Claude, Googleโ€™s Gemini, or OpenAIโ€™s ChatGPT. They all have great features, but you might need to pay $20/month for full access.
  2. When using these AIs, choose the right model for your needs. Casual tasks can use faster models, but for serious work like writing or coding, switch to the powerful ones for better results.
  3. Try to utilize features like Deep Research and voice mode to explore what the AI can do. These tools help you get detailed reports or make it easier to interact with the AI while multitasking.

How I Write Posts

Construction Physics โ€ข 21087 implied HN points โ€ข 19 Feb 24
๐ŸšŒ Education Research
  1. The author's writing process involves mainly two types of posts: explanation-driven and exploratory. They often write to understand complex topics themselves and then share their findings.
  2. Extensive research is a crucial part of the author's writing process. They gather information from a variety of sources like books, dissertations, and online resources.
  3. The author follows a structured approach starting from research, reading, and thinking, then moves on to compressing and structuring content, before finally drafting, editing, and posting their work.

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Marcus on AI โ€ข 8378 implied HN points โ€ข 22 Dec 24
๐Ÿ•น Technology Research
  1. Many experts feel that the recent test called ARC-AGI should not have been labeled as such. It wasn't a proper test for Artificial General Intelligence.
  2. The presentation was confusing and didn't clearly show what the AI was tested on. This left people with the impression that the AI performed better than it actually did.
  3. There's a need for more scientific scrutiny of the results. Until we get that, we can't really compare the AI's performance fairly with humans.

Physical Intelligence Sweeps Humanoid Olympics

General Robots โ€ข 348 implied HN points โ€ข 05 Jan 26
๐Ÿ•น Technology Research
  1. Physical Intelligence submitted robots for 11 humanoid Olympic events. They achieved these capabilities much sooner than expected, showing rapid progress in robotics.
  2. Many tasks that seemed to need special touch sensors or extra finger joints were actually solvable with standard grippers and cameras, and wrist force-torque sensing appears to help. This suggests clever hardware-software integration can overcome perceived limits.
  3. Teams make different trade-offs: some use more dexterous hands to collect teleoperation data while others add wrist force-torque sensors humans canโ€™t provide. Those choices change what sensor data and training each approach can use.

What is The Infinitesimal?

The Infinitesimal โ€ข 499 implied HN points โ€ข 05 Jul 24
๐Ÿ”ฌ Science Research
  1. Human traits are influenced by many tiny genetic factors, making understanding them complex. This means small changes in genetics can impact our traits in different ways.
  2. Talking about nature versus nurture isn't simple; both genetics and environment play big roles. There's often a mix of many genes working together rather than clear-cut definitions.
  3. The concept of heritability is tricky and often debated. Different studies can show very different results about how much genetics affect things like intelligence or behavior.

Pfizer and Moderna bivalent vaccines contain 20-35% expression vector and are transformation competent in E.coli

Nepetalactone Newsletter โ€ข 5405 implied HN points โ€ข 08 Mar 23
๐Ÿ”ฌ Science Research
  1. Pfizer and Moderna bivalent vaccines have 20-35% expression vector and can transform E.coli.
  2. Previous estimates of DNA contamination in the vaccines were significantly underestimated.
  3. Different methods like transformation of DNA in E.coli and qPCR assays were used to quantify the nucleic acid contamination in the vaccines.

On METR's AI Coding RCT

Don't Worry About the Vase โ€ข 2688 implied HN points โ€ข 18 Jul 25
๐Ÿ•น Technology Research
  1. A recent study found that using AI coding tools actually slowed down experienced developers by about 19%. This surprised many who expected them to speed up.
  2. The slowdown might be due to developers being very familiar with their own projects, which made it hard for AI to add value. Also, many participants didn't have enough experience using the AI tools.
  3. Self-reports from developers on their productivity are often unreliable. The study shows that just thinking you're faster with AI doesn't mean you really are.

DisInformation Chronicle Podcast with NIH Director Jay Bhattacharya

The DisInformation Chronicle โ€ข 290 implied HN points โ€ข 31 Dec 25
๐ŸŽ™ Podcasts Research
  1. A new podcast will interview interesting, smart thinkers and plans to release new episodes about twice a month at first.
  2. The first episode features NIH Director Jay Bhattacharya discussing his move from Stanford professor to the government role that manages a huge chunk of biomedical research funding.
  3. Future guests will be announced ahead of time so paid subscribers can suggest questions, and listeners are invited to suggest guests and consider subscribing.

Declining trust in Zeus is a technology

Experimental History โ€ข 20553 implied HN points โ€ข 31 Jan 24
๐Ÿ”ฌ Science Research
  1. Randomized-controlled trials are a relatively recent method in the history of scientific evidence.
  2. Challenging old beliefs, such as trust in ancient gods like Zeus, can lead to important scientific advancements.
  3. There is a need for more transparency and accessibility in expert knowledge to earn public trust in institutions and experts.

Yes, scientific progress depends on like a thousand people

The Intrinsic Perspective โ€ข 9247 implied HN points โ€ข 29 Oct 24
๐Ÿ”ฌ Science Research
  1. Scientific progress relies heavily on mentorship and connections within a large academic network. Many successful scientists come from the same elite lineage.
  2. Certain families of scientists are particularly influential, as seen with many Nobel Prize winners tracing back to a small number of academic mentors.
  3. While some critique the system as elitist, having a productive cultural substructure in science can be beneficial, and it's important to support this environment for future breakthroughs.

2026+

Gonzo ML โ€ข 315 implied HN points โ€ข 07 Jan 26
๐Ÿ•น Technology Research
  1. Quadruped robots (dog- or cat-like) will get much better and more practical for real-world use, while humanoid home robots stay too expensive.
  2. Weโ€™ll see production-grade agents with predictable 99.9% reliability and richer integrations, driven by better infrastructure and cognitive architectures.
  3. Advances in world models, latent-space reasoning, and multimodal architectures will create new interactive environments and begin to accelerate scientific discovery in certain domains.

Do Masks Work?

Uncharted Territories โ€ข 5149 implied HN points โ€ข 28 Feb 23
๐Ÿฅ Health & Wellness Research
  1. The debate around mask efficacy is contentious and the science is complex.
  2. Properly worn masks can reduce infection rates, especially when used in community settings.
  3. Some studies in the meta-analysis may have been weighted inaccurately, resulting in misleading conclusions.

England's ongoing Covid wave and new Long Covid research

Independent SAGE continues โ€ข 359 implied HN points โ€ข 19 Jul 24
๐Ÿฅ Health Politics Research
  1. England is experiencing a new wave of Covid-19, which has been ongoing and affecting many people's lives and plans.
  2. Recent research shows that being vaccinated significantly lowers the risk of developing Long Covid, but it's still a concern for a large number of people.
  3. Even with a lower chance of Long Covid now, frequent Covid waves mean that many people continue to suffer from long-term symptoms and disruption in their daily lives.

Maybe THIS Is Why You're Hangry

Harnessing the Power of Nutrients โ€ข 1817 implied HN points โ€ข 19 Mar 24
๐Ÿฅ Health & Wellness Research
  1. Feeling hangry might not always be due to low blood sugar, other factors like S-sulfocysteine levels in your urine could play a role in overstimulation symptoms.
  2. Elevated S-sulfocysteine, a neurostimulant, can result from breakdown of protein when hungry for glucose and may lead to various overstimulation symptoms like anxiety and muscle tension.
  3. Testing for S-sulfocysteine levels in urine should be more widely implemented to understand its potential impact on psychological traits and neuro-psychiatric diseases.

The Sequence Radar #807: Last Week in AI: From Mega-Rounds to Mathematical Breakthrough

TheSequence โ€ข 91 implied HN points โ€ข 15 Feb 26
๐Ÿ•น Technology Research
  1. Huge funding and strong enterprise revenue are accelerating AI research and infrastructure, letting big labs scale up ambitious agentic systems.
  2. Model and hardware advances are driving both extreme speed and open competition โ€” from ultra-fast self-debugging models on specialized chips to powerful open-weight models trained on domestic hardware.
  3. Agentic AI is maturing into professional tools: systems that generate, verify, and revise math proofs are hitting high benchmarks and solving open problems, showing AI can enhance scientific research.