Harnessing the Power of Nutrients

Chris Masterjohn, PhD's Substack 'Harnessing the Power of Nutrients' merges scientific insight with innovative thinking, focusing on health optimization through nutrition, genetic factors, and biochemistry. It challenges mainstream health narratives, explores nutrient impacts on health, and presents actionable advice based on personal health data and scientific research.

Nutritional Science Genetic Health Analysis Dietary Recommendations Mitochondrial Health Supplementation Metabolic Health Iron Metabolism Vaccine Analysis Health Policy Food Safety

The hottest Substack posts of Harnessing the Power of Nutrients

And their main takeaways

Join Me on the Mitochondrial Energy Summit!

838 implied HN points • 06 Jun 23
🏥 Health & Wellness Summit
  1. The Mitochondrial Energy Summit will run from June 20 through June 26, featuring talks from various experts in the field.
  2. The summit is free for everyone to attend, and registering early can get you additional free bonuses.
  3. Chris Masterjohn, PhD, will be presenting his talk live on day 6 of the summit, which is June 25.

What to Do About Constipation

758 implied HN points • 18 Aug 23
🏥 Health & Wellness Treatment Reviews
  1. Approximately 14% of the world's population suffers from constipation.
  2. Constipation is more common in women than in men and becomes more prevalent with age.
  3. Standard and alternative treatments, along with the causes of constipation, are discussed in the post.

Explaining the "Hospitalization Paradox"

3494 implied HN points • 19 Feb 22
🏥 Health & Wellness Public Health Vaccination Disease Inflammation Medical Research
  1. The "Hospitalization Paradox" highlights the vaccine's impact on PCR tests and COVID-like illness, creating a statistical anomaly exploited by media and health authorities.
  2. Vaccines may not be clinically useful as they predominantly impact the ability to test negative rather than reducing the severity of illness or hospitalization.
  3. During the waning phase of efficacy, the persistence of a negative test may correlate with undesirable inflammation, spike protein toxicity, autoimmunity, and COVID-like illness.

Unlocking the Power of Longevity

619 implied HN points • 15 Nov 23
🏥 Health & Wellness Longevity Nutrition Diet Health
  1. Longevity studies often rely on questionable animal models like worms and jellyfish to draw conclusions, but humans have specific causes of death.
  2. Rather than searching for a universal principle of aging, focusing on preventing the actual causes of death can contribute to a longer and healthier life.
  3. Nutrition played a major role in battling diseases before antibiotics, and prioritizing it over disease-specific pharmaceuticals can be a key to longevity.
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Can Biotin Help Detoxify Oxalate?

1318 implied HN points • 06 Feb 23
🏥 Health & Wellness Nutrition Supplements Detoxification Alternative Medicine
  1. The hypothesis presented suggests that biotin-dependent enzyme pyruvate carboxylase may detoxify oxalate by converting it to formate, which could then be utilized in methylation or further metabolism.
  2. Biotin deficiency might lead to oxalate intolerance, implying the importance of biotin in promoting oxalate clearance.
  3. The interesting discussion around biotin and oxalate interactions opens up possibilities for further research into how biotin may play a role in detoxifying oxalate, potentially impacting how we approach certain health conditions.

The Greatest Error in Microbiome Research

1198 implied HN points • 03 Mar 23
🏥 Health & Wellness
  1. Lab animals, like rats and mice, eat their own microbiome as a normal part of their diet, which researchers often overlook in microbiome studies
  2. The process of coprophagy, where animals consume their feces, is more common in smaller herbivorous mammals and serves as a nutritional strategy for nutrient recycling and absorption
  3. Food and vitamin absorption in the colon may offer some support to colonic cells, but its impact on overall nutritional status for the body is likely minimal compared to the small intestine

The 3 things Bryan Johnson is missing from his longevity routine.

499 implied HN points • 17 Dec 23
🏥 Health & Wellness Longevity Anti-aging Self-experimentation Healthy Lifestyle
  1. Bryan Johnson is dedicated to finding anti-aging strategies and sharing them with the world, even if his methods are extreme.
  2. It's important to seek high-impact actions that can improve longevity without sacrificing important aspects of life like relationships, enjoyment, and financial freedom.
  3. Taking steps to optimize health and longevity sooner rather than later is crucial, as aging processes can accelerate and become irreversible if left unaddressed.

The "Health Super Unlock" Video and Podcast

659 implied HN points • 08 Oct 23
🏥 Health & Wellness Nutrition Wellness
  1. Focus on finding the root causes of health issues instead of just treating symptoms with drugs and supplements.
  2. The 'Health Super Unlock' content, previously available only in written form, can now be accessed as a video or podcast for free for the next 48 hours.
  3. Maintain good health through basic practices like eating nutritious foods, staying active, sleeping well, and nurturing positive relationships.

Why Would Citrate or Malate Cause Insomnia?

659 implied HN points • 18 Aug 23
🏥 Health & Wellness Nutrition Insomnia Metabolism Supplements
  1. Citrate and malate in supplements can cause insomnia for different people, suggesting individual differences in energy metabolism.
  2. The opposite reactions to citrate and malate indicate underlying idiosyncrasies in energy metabolism.
  3. Consider exploring metabolic issues or mold contamination as possible reasons for experiencing insomnia from citrate or malate supplements.

The Fasting-Feeding Reset

1158 implied HN points • 31 Jan 23
🏥 Health & Wellness Fasting Supplements Immune System
  1. The concept of a Fasting-Feeding Reset involves stacking supplements to optimize both fasting and feeding states for tissue health.
  2. Fasting is not suitable for everyone, especially pregnant/lactating women, children, or those with certain medical conditions.
  3. The fasting-feeding reset approach aims to clean up damaged tissue during fasting and rebuild healthy tissue during feeding for immune system improvements.

Comprehensive Nutritional Screening

619 implied HN points • 30 Jul 23
🏥 Health & Wellness Nutrition
  1. Comprehensive nutritional screening is important for overall health and well-being.
  2. There are specific tests that can provide a comprehensive overview of an individual's nutritional status.
  3. Paid subscribers can access detailed information on the best methods for comprehensive nutritional testing.

Jinfiniti "Total Antioxidant Capacity" -- Worth It?

399 implied HN points • 18 Dec 23
🏥 Health & Wellness Antioxidants Oxidative stress Energy metabolism
  1. Jinfiniti's 'Total Antioxidant Capacity' test is not precise and may not be worth investing in.
  2. The commonly used FRAP and ORAC assays for antioxidant status assessment are non-specific and may not provide meaningful information.
  3. A more effective approach involves a comprehensive screening for energy metabolism and antioxidant components to identify specific areas for optimization.

Why High-Dose Biotin Could be the Answer for Your Blood Sugar, Neurological Health, and Skin Health

539 implied HN points • 18 Oct 23
🏥 Health & Wellness Nutrition Supplements Health Conditions
  1. High-dose biotin can have varied effects on health, improving blood sugar and some sensory issues but potentially worsening neurological problems.
  2. Studies have shown positive impacts on diabetes and sensory issues with high-dose biotin, but caution is needed due to potential adverse effects.
  3. Biotin supplementation levels should be tailored individually, as too much can lead to misleading lab test results and impact health negatively.

New Q&A Format for July

519 implied HN points • 02 Jul 23
🎭️ Culture Newsletter
  1. The post introduces a new Q&A format for July, which is an experimental change and the audience will have a say in its success.
  2. Feedback on the new Q&A format is encouraged in the comments, with a specific request not to submit questions for the contest on this post.
  3. The post is for paid subscribers only, with an invitation to subscribe for access to the new Q&A format.

Download "Understanding Iron"

79 implied HN points • 01 Jun 24
🏥 Health & Wellness Nutrition
  1. The post is about understanding iron and is for paid subscribers only.
  2. Masterpass members can download a print-friendly PDF of "Understanding Iron."
  3. The post by Chris Masterjohn, PhD, provides valuable information on the topic.

Questions on Blood Glucose and Oxalate

639 implied HN points • 01 May 23
🏥 Health & Wellness Nutrition Supplements Q&A
  1. Postprandial blood glucose should be kept under 140 mg/dL to avoid compromising metabolism and antioxidant status.
  2. Minimizing oxalate absorption can be achieved by consuming 300-400 mg calcium at each meal and maintaining postprandial urine pH in the 6.4-6.8 range.
  3. Reducing dietary oxalate intake is crucial to prevent potential gut damage.

Did the Pfizer Trial Show the Vaccine Increases Heart Disease Deaths?

2256 implied HN points • 19 Feb 22
🏥 Health Politics Vaccine Safety Clinical Trials
  1. The Pfizer trial did not show a statistically significant increase in all-cause mortality or cardiac mortality among vaccinated individuals
  2. The trial would have needed to be longer for significant differences to show, suggesting the need for longer trials in vaccine studies
  3. It's important to consider all possible risks found in trials seriously, even when statistically insignificant, and to approach vaccine research with caution

Questions on hair trace mineral analysis, the real problem with seed oils, and the supposed vitamin C tyrosinase complex.

479 implied HN points • 28 Jun 23
🏥 Health & Wellness Nutrition Minerals Vitamins Toxins Supplements
  1. Hair trace mineral analysis can capture unique data but should be complemented with more validated tests for accurate results
  2. Seed oils pose a concern due to their susceptibility to oxidative damage, which can be addressed by consuming specific nutrients in moderation
  3. Whole food vitamin C is similar to synthetic forms in its functions, but obtaining it from natural sources can offer additional benefits

In case you missed my mitochondrial energy talk...

459 implied HN points • 30 Jun 23
🏥 Health & Wellness Metabolism Nutrition Genetics Energy Health
  1. The Mitochondrial Energy Summit is hosting an 'Encore Weekend' event starting at 6 PM eastern time tonight, allowing those who missed the original airing to catch up.
  2. Attendees have praised the talk for its valuable insights on energy metabolism and nutrition, sparking discussions on lifestyle changes like consuming superfoods more regularly.
  3. Chris Masterjohn's talk has received glowing reviews, with attendees expressing appreciation for his knowledge, dedication, and balanced approach to discussing the intersection of genetics and nutrition.

Why You Need THIS Supplement On a High-Protein Diet

419 implied HN points • 16 Oct 23
🏥 Health & Wellness Nutrition Supplements
  1. Eating a high-protein diet may not provide enough biotin, especially for athletes experiencing skin issues, blood sugar imbalances, or low mood.
  2. Consider supplementing with biotin if you are on a protein-rich diet and facing related symptoms.
  3. Check out the video and podcast resources for more information on the importance of biotin in a high-protein diet.

The Emerging Food Crisis

1817 implied HN points • 28 Mar 22
🍲 Food & Drink Farming Resilience Community support
  1. The emerging food crisis is not primarily caused by the conflict in Ukraine and a peaceful resolution to that conflict will not avert it.
  2. The crisis is driven by low supplies of fuel, chemical fertilizer, glyphosate, labor, and properly working equipment, impacting different farms to varying degrees.
  3. To prepare for rising food prices, consider supporting local farms, buying food with long shelf-lives, and gradually increasing your food supply based on the inflation trends and expert insights.

What I'm Doing for Allergies

1617 implied HN points • 11 May 22
🏥 Health & Wellness Allergies Supplements Diet Vitamins Mental health
  1. Implementing a protocol for allergies involves a combination of supplements and changes in diet and lifestyle, such as incorporating spirulina, herbs like Tinofend, and hyperlocal honey.
  2. Personalized allergy protocols may require adjustments based on individual nutrient needs, such as increasing intake of specific nutrients like choline, methylfolate, vitamin A, and vitamin C.
  3. Considering historical changes in diet and lifestyle that have impacted allergy severity can provide insights for developing effective allergy management strategies.

Adventures in Zone 2 Cardio Training | Part 1

1118 implied HN points • 29 Sep 22
🏥 Health & Wellness Fitness Training Metabolism Endurance Measurement
  1. Zone 2 cardio training is essential for metabolic health and involves moderate intensity fat-burning exercise that can be sustained for an hour.
  2. Training in Zone 2 can improve endurance, fat oxidation, and lactate clearance in slow-twitch muscle fibers, benefiting overall fitness and potentially impacting fasting tolerance.
  3. Measuring lactate levels using a meter provides precise feedback for optimal training intensity in Zone 2, leading to rapid progress and efficient workouts.

The Mitochondrial Summit Starts Today!

419 implied HN points • 20 Jun 23
🏥 Health & Wellness Summit Health Learning
  1. The Mitochondrial Summit starts today and runs through June 26, covering various topics like red light, PEMF, toxic dental products, and more.
  2. Several notable speakers will be at the summit, including Terry Wahls, Stephanie Seneff, Morley Robbins, and more throughout the week.
  3. Registering with the provided link grants free entrance to the summit, offering a valuable opportunity for learning and expanding knowledge on mitochondrial health.

Three Health Issues Converge on One Bone

878 implied HN points • 09 Dec 22
🏥 Health & Wellness Nutrition Physical therapy Medical Testing
  1. Three health issues, including neurological problems and hearing loss, can converge on a little bony protuberance in the temporal bone behind the ear.
  2. Mild biotin deficiency may play a significant role in various health issues, requiring a careful balance of nutrients like biotin, pantothenic acid, and lipoic acid for resolution.
  3. Structural misalignment, such as a bent and twisted coccyx, can impact various health problems, including head tension and Eustachian tube dysfunction, ultimately affecting hearing and other neurological functions.

What Causes Long-COVID?

918 implied HN points • 14 Nov 22
🏥 Health & Wellness Long Covid Immune System Antioxidants
  1. Long-COVID, also known as post-acute sequelae of COVID-19, can present with a variety of symptoms that persist beyond the acute infection phase, with fatigue and breathing difficulties being common.
  2. Risk factors for developing long-COVID include the severity of the initial COVID illness and being female. Female sex is a consistent risk factor, possibly due to survivorship bias.
  3. The three main hypotheses to explain long-COVID are microclots, persistent antigen, and immune dysfunction. These factors may contribute to lingering symptoms and complications in long-COVID patients.

Time to VOTE on the Questions

379 implied HN points • 17 Jul 23
🚌 Education
  1. Voting on questions for a contest closes on July 19th at midnight Eastern time.
  2. To participate in the voting, use the provided link for the July Question Contest.
  3. The post is accessible only to paid subscribers.

Winner and Runners Up for the July 2023 Question Contest

379 implied HN points • 20 Jul 23
🏥 Health & Wellness Research Health tips Nutrition
  1. The July 2023 Question Contest winners focused on researched articles about methylene blue, constipation, and DNA testing, each accompanied by video and podcast content.
  2. The winning question in the contest was about methylene blue and its potential for improving mitochondrial health, drawing attention to the balance between real evidence and hype in the biohacking community.
  3. This post is accessible to paid subscribers only, encouraging individuals to subscribe to get access to detailed content and insights.

Thyroid Toxins: Double-Edged Swords of the Kingdom Plantae

858 implied HN points • 25 Nov 22
🏥 Health & Wellness Thyroid Health Toxins Plant-based diet
  1. Be cautious with millet consumption as not all processed foods labeled as millet contain the type of millet discussed in the report.
  2. The understanding of hormesis mechanisms has improved significantly since 2007, providing an updated perspective on beneficial toxins.
  3. Consider subscribing to further explore these topics and gain access to additional insights.

Does Nicotinamide Riboside Fuel Cancer Growth?

818 implied HN points • 22 Nov 22
🏥 Health & Wellness Nutrition Cancer Supplementation Prevention Research
  1. A new study highlights the concern that nicotinamide riboside (NR) could potentially fuel cancer growth, especially in the case of triple-negative breast cancer.
  2. The study utilized mice models to show that NR supplementation could lead to increased tumor prevalence and metastasis in triple-negative breast cancer cells.
  3. The research suggests that the strategies for preventing cancer differ from those required for treating cancer, emphasizing the importance of nourishing detoxification and immune surveillance.

A New Paradigm for Severe COVID

1298 implied HN points • 22 May 22
  1. Severe COVID is marked by depletion of lymphocytes and a rise in myeloid-derived suppressor cells (MDSCs), which suppress T cells and increase the risk of death.
  2. Understanding why MDSCs arise and persist may lead to a breakthrough in our understanding of severe COVID, with a focus on depletion of myeloid differentiation factors like vitamins A and D.
  3. Nutritional strategies can include balancing vitamins A and D, repleting amino acids like arginine and tryptophan, and providing antioxidants and anti-glycation nutrients to counter T cell suppression and damage in severe COVID cases.